Nos2 - nitric oxide synthase 2, inducible Gene

Also Known as iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18126

About Nos2

Chromosome 11: 78,811,613-78,851,080 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 136 phenotypes. Biased expression in large intestine adult (RPKM 3.6), ovary adult (RPKM 13.) and 6 other tissues.

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nos2 Products (3)

mRNA Protein Name
NM_010927.4 NP_035057.1 nitric oxide synthase, inducible isoform a
NM_001313922.1 NP_001300851.1 nitric oxide synthase, inducible isoform b
NM_001313921.1 NP_001300850.1 nitric oxide synthase, inducible isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FMN binding IDA
IDA: Inferred from direct assay
1383204 MGI
enables arginine binding IDA
IDA: Inferred from direct assay
9271491 MGI
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
1383204 MGI
enables heme binding IDA
IDA: Inferred from direct assay
1383204 MGI
enables nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
1383204 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12855682 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9271491 MGI
enables tetrahydrobiopterin binding IDA
IDA: Inferred from direct assay
9271491 MGI
Biological Process GO Annotation Evidence References Source
involved in arginine catabolic process IDA
IDA: Inferred from direct assay
1383204 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
24486487 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
22073225 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
12933833 MGI
involved in negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
12085352 MGI
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
18003616 MGI
involved in nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
1383204 MGI
NOT acts upstream of or within ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
11779605 MGI
involved in peptidyl-cysteine S-nitrosylation IDA
IDA: Inferred from direct assay
16373578 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
11606502 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
12960352 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
22073225 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
12933833 MGI
Cellular Component GO Annotation Evidence References Source
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
12960352 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11732991 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12960352 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nos2 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (77 - 489)

Flavodoxin_1

Flavodoxin_1: pfam00258 (534 - 665)

FNR_like

FNR_like: cl06868 (729 - 1125)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1144 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, inducible

  • NOS type II

  • inducible NO synthase

  • inducible NOS

  • inducible nitric oxide synthase

  • macrophage NOS

  • nitric oxide synthase 2, inducible, macrophage

  • peptidyl-cysteine S-nitrosylase NOS2

Nos2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nos2 P29477 Rela Mus musculus Q04207
Anti Tag CoIP
21464294
Intra
Nos2 P29477 Rela Mus musculus Q04207
Anti Bait CoIP
21464294
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos2 NCBI NCBI:4843