2. Gene
  3. Nos2 - nitric oxide synthase 2, inducible Gene

Nos2 - nitric oxide synthase 2, inducible Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS

Gene ID: 18126 | Gene type: protein coding

About Nos2

Chromosome 11: 78,811,613-78,851,080 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 136 phenotypes. Biased expression in large intestine adult (RPKM 3.6), ovary adult (RPKM 13.) and 6 other tissues.

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nos2 Products(3)

mRNA Protein Name
NM_010927.4 NP_035057.1 nitric oxide synthase, inducible isoform a
NM_001313922.1 NP_001300851.1 nitric oxide synthase, inducible isoform b
NM_001313921.1 NP_001300850.1 nitric oxide synthase, inducible isoform b

Nos2 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (77 - 489)

Flavodoxin_1

Flavodoxin_1: pfam00258 (534 - 665)

FNR_like

FNR_like: cl06868 (729 - 1125)

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  • 1144 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, inducible

NOS type II

inducible NO synthase

inducible NOS

inducible nitric oxide synthase

macrophage NOS

nitric oxide synthase 2, inducible, macrophage

peptidyl-cysteine S-nitrosylase NOS2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12124 BBS-4 Inhibitor 99.51% Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-RS09437 NOS2 Human Pre-designed siRNA Set A / Unkown
HY-RS09438 Nos2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09439 NOS2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos2 NCBI NCBI:4843