Cdk16 - cyclin-dependent kinase 16 Gene

Also Known as Crk5; Pctk1; Pctaire1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18555

About Cdk16

Chromosome X: 20,554,193-20,566,119 forward strand.GRCm39:CM001013.3

This gene has 8 transcripts (splice variants), 174 orthologues, 25 paralogues and is associated with 8 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 14.3), adrenal adult (RPKM 9.2) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including regulation of Insulin secretion involved in cellular response to glucose stimulus; secretion by cell; and spermatogenesis. Colocalizes with synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Apr 2022]

Cdk16 Products (8)

mRNA Protein Name
NM_011049.6 NP_035179.1 cyclin-dependent kinase 16 isoform 1
NM_001411705.1 NP_001398634.1 cyclin-dependent kinase 16 isoform 1
NM_001411707.1 NP_001398636.1 cyclin-dependent kinase 16 isoform 2
NM_001310456.2 NP_001297385.1 cyclin-dependent kinase 16 isoform 2
NM_001310456.2 NP_001297385.1 cyclin-dependent kinase 16 isoform 2
NM_001411705.1 NP_001398634.1 cyclin-dependent kinase 16 isoform 1
NM_001411707.1 NP_001398636.1 cyclin-dependent kinase 16 isoform 2
NM_011049.6 NP_035179.1 cyclin-dependent kinase 16 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22184064 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16461345 MGI
Biological Process GO Annotation Evidence References Source
involved in exocytosis IMP
IMP: Inferred from mutant phenotype
16461345 MGI
involved in growth hormone secretion IMP
IMP: Inferred from mutant phenotype
16461345 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
20534669 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
21335063 MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22798068 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
22184064 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26305884 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
26305884 MGI
colocalizes with synaptic vesicle IDA
IDA: Inferred from direct assay
16461345 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk16 Protein Structure

STKc_PCTAIRE1

STKc_PCTAIRE1: cd07873 (161 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 16

  • PCTAIRE-motif protein kinase 1

  • cell division protein kinase 16

  • serine/threonine-protein kinase PCTAIRE-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-148063 DB0614 99.92% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-160213 JA397 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk16 NCBI NCBI:5127