Prl - prolactin Gene
Also Known as Gha1; Prl1a1
Species: Mus musculus
Gene Type: protein coding
Gene ID: 19109
Summary
Predicted to enable hormone activity and Prolactin receptor binding activity. Acts upstream of or within several processes, including mammary gland development; maternal behavior; and positive regulation of receptor signaling pathway via JAK-STAT. Located in secretory granule. Is expressed in hippocampus; pituitary gland; placenta; and trophoblast giant cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (Prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Prl Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001163530.1 | NP_001157002.1 | prolactin isoform 2 precursor |
| NM_011164.2 | NP_035294.2 | prolactin isoform 1 precursor |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in secretory granule |
IDA
IDA: Inferred from direct assay
|
9247267 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
prolactin |
|
Recombinant Prl Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73381 | Prolactin Protein, Mouse (sf9, His) | P06879 (L30-C226) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P700261 | Prolactin Protein, Mouse (His) | P06879 (L30-C226) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(6)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-B0537 | Pentamidine | Inhibitor | 97.19% | Unkown |
| HY-B0537B | Pentamidine isethionate | Inhibitor | 99.95% | Yes |
| HY-U00051 | Propiomazine | 98.91% | Unkown | |
| HY-B0537C | Pentamidine dimesylate | Inhibitor | / | Unkown |
| HY-U00051A | Propiomazine hydrochloride | Inhibitor | / | Unkown |
| HY-B0537A | Pentamidine dihydrochloride | Inhibitor | / | Unkown |
Clinical Phase
Inhibitory Antibodies
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-P991358 | XOMA-213 | Inhibitor | 98.46% | Phase 1 |
Pre-clinical Phase
Bioactive Molecules
(20)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-112476 | PRL-3 Inhibitor I | Inhibitor | 98.11% | Unkown |
| HY-128153 | Thienopyridone | 95.14% | Unkown | |
| HY-P4452 | PRL 2915 | 99.92% | Unkown | |
| HY-131547 | Org OD 02-0 | 99.7% | Unkown | |
| HY-103079 | PRL-3 Inhibitor 2 | Inhibitor | 99.12% | Unkown |
| HY-B0537AS | Pentamidine-d4 dihydrochloride | Inhibitor | 98.49% | Unkown |
| HY-P4469 | PRL 3195 | / | Unkown | |
| HY-W043170 | PRL3-CNNM4 PPI-IN-1 | Inhibitor | 99.33% | Unkown |
| HY-13976A | PRL-8-53 | / | Unkown | |
| HY-162119 | PRL-IN-1 | Inhibitor | / | Unkown |
| HY-171035 | PRL-295 | Inhibitor | / | Unkown |
| HY-P4523 | FA-Ala-Arg | / | Unkown | |
| HY-RS11160 | PRL Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-U00051AS | Propiomazine-d6 hydrochloride | Inhibitor | / | Unkown |
| HY-U00051AS1 | (R)-Propiomazine-d6 hydrochloride | / | Unkown | |
| HY-U00051AS2 | (S)-Propiomazine-d6 hydrochloride | / | Unkown | |
| HY-U00051B | Propiomazine maleate | / | Unkown | |
| HY-114877 | CG-707 | Inhibitor | / | Unkown |
| HY-RS16777 | Prl Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS23217 | Prl Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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