EEF1B2 - eukaryotic translation elongation factor 1 beta 2 Gene

Also Known as EF1B; EEF1B; EEF1B1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1933

About EEF1B2

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:206,159,609-206,162,928 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 182 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 282.5), lymph node (RPKM 249.8) and 25 other tissues.

Summary

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

EEF1B2 Products (3)

mRNA Protein Name
NM_001037663.2 NP_001032752.1 elongation factor 1-beta
NM_001959.4 NP_001950.1 elongation factor 1-beta
NM_021121.4 NP_066944.1 elongation factor 1-beta

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8743958 GOA
colocalizes with endoplasmic reticulum IDA
IDA: Inferred from direct assay
8743958 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1B2 Protein Structure

EF-1_beta_acid

EF-1_beta_acid: Eukaryotic elongation factor 1 beta central acidic region (103 - 130)

EF1_GNE

EF1_GNE: EF-1 guanine nucleotide exchange domain (139 - 225)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

elongation factor 1-beta

  • EF-1-beta

EEF1B2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641-2
Validated Y2H
25416956
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641
Validated Y2H
32296183
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641
Y2H Array
32296183
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641
Y2H Pooling
16189514
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641
Y2H Prey Pooling
32296183
Intra
EEF1B2 P24534 EEF1G Homo sapiens P26641
Y2H Pooling
16169070
Intra
EEF1B2 P24534 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EEF1B2 P24534 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
EEF1B2 P24534 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EEF1B2 P24534 SPRYD4 Homo sapiens Q8WW59
Y2H Prey Pooling
32296183
Intra
EEF1B2 P24534 SPRYD4 Homo sapiens Q8WW59
Validated Y2H
32296183
Intra
EEF1B2 P24534 SPRYD4 Homo sapiens Q8WW59
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EEF1B2 Proteins

Cat. No. Product Name Accession Purity
HY-P76898 EEF1B2 Protein, Human (His) P24534 (G2-I225) ≥ 90%, as determined by reducing SDS-PAGE.

EEF1B2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85844 EF-1β Antibody (YA5536) WB, IHC-P, ICC/IF, ELISA Human, Mouse

Related Diseases

Diseases Alias
Cystic Echinococcosis

  • Echinococcus Granulosus Infection

  • Echinococcus Granulosus Infection Of Lung

  • Echinococcus Granulosus

  • Echinococcus Granulosus Infection Of Thyroid

  • Echinococcus Granulosus Infectious Disease

  • Echinococcus Granulosus Infectious Disease Of Liver

  • Echinococcus Granulosus Infectious Disease Of Thyroid

  • Liver Echinococcus Granulosus

  • Lung Echinococcus Granulosus

  • Thyroid Echinococcus Granulosus

  • Unilocular Echinococcosis

  • Unilocular Hydatid Disease

  • Hydatid Disease

  • Hydatidosis

  • Echinococcosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04176 EEF1B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19059 Eef1b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25549 Eef1b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EEF1B2 MGD MGI:1929520
Macaca mulatta EEF1B2 VGNC VGNC:104523
Rattus norvegicus EEF1B2 RGD RGD:1311415
Bos taurus EEF1B2 VGNC VGNC:54422
Felis catus EEF1B2 VGNC VGNC:82529
Canis familiaris EEF1B2 VGNC VGNC:57381
Others EEF1B2 NCBI