Ski - ski sarcoma viral oncogene homolog (avian) Gene

Also Known as 2310012I02Rik; 2610001A11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20481

Summary

Enables chromatin binding activity and histone deacetylase inhibitor activity. Acts upstream of or within several processes, including animal organ development; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in embryo; forelimb bud; and forelimb interdigital region. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ski Products (2)

mRNA Protein Name
NM_001357191.1 NP_001344120.1 ski oncogene isoform 2
NM_011385.2 NP_035515.2 ski oncogene isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IGI
IGI: Inferred from genetic interaction
19008232 MGI
enables histone deacetylase inhibitor activity IGI
IGI: Inferred from genetic interaction
17352741 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12435627 MGI
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
10049357 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
11731796 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
9284043 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
11731796 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
17003410 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
12435627 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
9284043 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
11781823 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
17003410 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
15312649 MGI
acts upstream of or within myotube differentiation IDA
IDA: Inferred from direct assay
17352741 MGI
acts upstream of or within myotube differentiation IGI
IGI: Inferred from genetic interaction
19008232 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
21937600 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
11781823 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7659522 MGI
involved in negative regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
10049357 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21937600 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
9284043 MGI
acts upstream of or within nose morphogenesis IMP
IMP: Inferred from mutant phenotype
11731796 MGI
acts upstream of or within olfactory bulb development IMP
IMP: Inferred from mutant phenotype
11731796 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7659522 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19008232 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
17003410 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
11731796 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
9284043 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
19379700 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12435627 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7823166 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
19008232 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12435627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ski oncogene

  • C-ski

  • Sloan-Kettering viral oncogene homolog

  • proto-oncogene c-Ski

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10158 Bosutinib 99.97% Yes
HY-10158A Bosutinib hydrate Inhibitor 99.97% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13822 SKI II 99.25% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-12892 SKI-178 99.29% Unkown
HY-162143 SKI-349 Inhibitor 99.48% Unkown
HY-19325 SKI2852 Inhibitor 98.89% Unkown
HY-115735 SKI-I 99.73% Unkown
HY-12895 SKI V 98.95% Unkown
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% Unkown
HY-N4308 Hexamethylquercetagetin Inhibitor 98.0% Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-10158S Bosutinib-d8 ≥99.0% Unkown
HY-117563 CAY10621 Inhibitor 99.3% Unkown
HY-10158S1 Bosutinib-13C,d3 / Unkown
HY-10158AR Bosutinib hydrate (Standard) Inhibitor / Unkown
HY-106588 Heptaplatin / Unkown
HY-161441 SIK-IN-2 Inhibitor / Unkown
HY-161442 SIK-IN-3 Inhibitor / Unkown
HY-RS12969 SKI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114206 SKI-73 / Unkown
HY-117982 SKI2496 / Unkown
HY-RS18593 Ski Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25078 Ski Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W714171 Propoxycarbazone sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ski NCBI NCBI:6497