NR2F6 - nuclear receptor subfamily 2 group F member 6 Gene

Homo sapiens

Also known as EAR2; EAR-2; ERBAL2

Gene ID: 2063 | Gene type: protein coding

About NR2F6

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,231,883-17,245,919 (from NCBI)

This gene has 2 transcripts (splice variants), 285 orthologues and 11 paralogues. Broad expression in colon (RPKM 27.8), stomach (RPKM 20.8) and 23 other tissues.

Summary

Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NR2F6 Products(1)

mRNA	Protein	Name
NM_005234.4	NP_005225.2	nuclear receptor subfamily 2 group F member 6

NR2F6 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 2 group F member 6

ERBA-related gene-2

Related Diseases

Diseases

Alias

Sebaceous Adenocarcinoma

Sebaceous Carcinoma	Adenocarcinoma Of The Sebaceous Gland
Malignant Neoplasm Of Sebaceous Gland	Malignant Sebaceous Tumor
Adenocarcinoma, Sebaceous	Malignant Sebaceous Neoplasm
Sebaceous Gland Neoplasms

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-147228	NR2F6 modulator-1	99.74%	Unkown
HY-156190	NR2F2-IN-1	/	Unkown
HY-RS09543	NR2F6 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NR2F6	MGD	MGI:1352453
Felis catus	NR2F6	VGNC	VGNC:68552
Macaca mulatta	NR2F6	VGNC	VGNC:75514
Rattus norvegicus	NR2F6	RGD	RGD:621685
Canis familiaris	NR2F6	VGNC	VGNC:43951
Bos taurus	NR2F6	VGNC	VGNC:32242

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