Sp1 - trans-acting transcription factor 1 Gene

Also Known as Sp1-1; 1110003E12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20683

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and response to hydroperoxide. Acts upstream of or within several processes, including animal organ development; embryo development; and mRNA transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; epithelium; eye; and genitourinary system. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp1 Products (1)

mRNA Protein Name
NM_013672.2 NP_038700.2 transcription factor Sp1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9738004 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19943855 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
1524678 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12119294 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22331133 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8617793 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
12657651 MGI
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
12657651 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9705320 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
15282343 MGI
contributes to protein binding IPI
IPI: Inferred from physical interaction
10215616 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1909605 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11071760 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within definitive hemopoiesis IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic placenta development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic process involved in female pregnancy IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within enucleate erythrocyte differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22331133 MGI
acts upstream of or within megakaryocyte differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within myeloid progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within ossification IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15282343 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
24030830 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
1524678 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14701757 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15663180 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21029371 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12119294 MGI
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27918959 MGI
involved in response to hydroperoxide IDA
IDA: Inferred from direct assay
27918959 MGI
acts upstream of or within trophectodermal cell differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21029371 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9705320 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp1

  • specificity protein 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0122 Plicamycin Inhibitor 99.60% Unkown
HY-100008 Peretinoin 99.79% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10447 Terameprocol 99.50% Phase 2
HY-N0842 Bevirimat Inhibitor 99.82% Phase 2
HY-P10603 SP1 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W040129 Chromomycin A3 99.66% Unkown
HY-W100287 Murrayafoline A Inhibitor 99.73% Unkown
HY-N7078 Spiculisporic acid 99.88% Unkown
HY-179528 DIM-3,5-Cl2 99.18% Unkown
HY-P10336 Serpinin Agonist 98.74% Unkown
HY-RS13600 SP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W006646 Methyl 5-bromo-1H-pyrrole-2-carboxylate 98.43% Unkown
HY-113542 Blasticidin A Inhibitor 95% Unkown
HY-125538 Deoxybrevianamide E 99.2% Unkown
HY-RS16562 Sp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29499 SP1 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012589 tert-Pentylbenzene 98.85% Unkown
HY-114585A Sperabillin A dihydrochloride Inhibitor / Unkown
HY-116077 AB 5046B / Unkown
HY-120764 PF-46396 Inhibitor / Unkown
HY-125458 Iromycin A Inhibitor / Unkown
HY-129931 Phenylalanylphenylalanylamide / Unkown
HY-137462 Leucyl-phenylalanine amide / Unkown
HY-150536 EP39 Inhibitor / Unkown
HY-178021 HDAC1-IN-11 / Unkown
HY-178022 HDAC6-IN-63 / Unkown
HY-178143 Sp1-IN-1 Inhibitor / Unkown
HY-184699 AKR1C3-IN-16 Inhibitor / Unkown
HY-N12266 12-Hydroxyalbrassitriol / Unkown
HY-N16411 Carneamide A / Unkown
HY-N17478 (3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol / Unkown
HY-N19796 Diaporol I / Unkown
HY-N8662 Primulic acid II / Unkown
HY-P11688 Fmoc-PNA-M(Bhoc)-OH / Unkown
HY-P11689 Fmoc-PNA-J(Bhoc)-OH / Unkown
HY-P1330 Purotoxin 1 Inhibitor / Unkown
HY-P3805 [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) Antagonist / Unkown
HY-RS03522 DAND5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11279 PSG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108993 Fujianmycin B / Unkown
HY-120551 Fructigenine A / Unkown
HY-123036 Renierone Inhibitor / Unkown
HY-184043 Pinazaphilone A / Unkown
HY-184835 Uranyl acetate / Unkown
HY-N0980 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid / Unkown
HY-N12149 Axinysone B Inhibitor / Unkown
HY-N13017 Bhimanone / Unkown
HY-N14206 Cytosporin B / Unkown
HY-N14403 6-Hydroxytetrangulol Activator / Unkown
HY-N14576 Pyrrolomycin C Inhibitor / Unkown
HY-N14577 Pyrrolomycin D Inhibitor / Unkown
HY-N2657 Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate / Unkown
HY-N8339 Decatromicin B Inhibitor / Unkown
HY-N8391 Hydroxysulochrin / Unkown
HY-N8849 4-Methyl-6,7-methylenedioxycoumarin Inhibitor / Unkown
HY-RS22994 Sp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp1 NCBI NCBI:6667