Prdx2 - peroxiredoxin 2 Gene

Also Known as TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21672

Summary

Predicted to enable thioredoxin peroxidase activity. Involved in positive regulation of blood coagulation and removal of superoxide radicals. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and respiratory burst involved in inflammatory response. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; limb; reproductive system; and sensory organ. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]

Prdx2 Products (2)

mRNA Protein Name
NM_001317385.1 NP_001304314.1 peroxiredoxin-2
NM_011563.6 NP_035693.3 peroxiredoxin-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17141802 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
15259009 MGI
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
15259009 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15259009 MGI
acts upstream of or within hydrogen peroxide catabolic process IMP
IMP: Inferred from mutant phenotype
15902258 MGI
acts upstream of or within hydrogen peroxide metabolic process IMP
IMP: Inferred from mutant phenotype
15259009 MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
17325201 MGI
acts upstream of or within negative regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
16290204 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15259009 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
9115640 MGI
acts upstream of or within negative regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17325201 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
17325201 MGI
involved in positive regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
20978343 MGI
acts upstream of or within regulation of hydrogen peroxide metabolic process IMP
IMP: Inferred from mutant phenotype
17325201 MGI
involved in removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
20978343 MGI
acts upstream of or within respiratory burst involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
17325201 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17325201 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
15259009 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxiredoxin-2

  • Calpromotin

  • Prx II-1

  • Trx dependent peroxide reductase 1

  • protector protein

  • thiol-specific antioxidant protein

  • thioredoxin peroxidase 1

  • thioredoxin reductase

  • thioredoxin-dependent peroxide reductase 1

  • thioredoxin-dependent peroxiredoxin 2

Recombinant Prdx2 Proteins

Cat. No. Product Name Accession Purity
HY-P73712 Peroxiredoxin-2/PRDX2 Protein, Mouse (sf9, His) Q61171/NP_035693.3 (M1-N198) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1324 Oxiconazole nitrate 98.0% Yes
HY-B1324A Oxiconazole / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11075 PRDX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17423 Prdx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23878 Prdx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdx2 NCBI NCBI:7001