Tnc - tenascin C Gene

Also Known as TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21923

Summary

Predicted to enable fibronectin binding activity and syndecan binding activity. Acts upstream of or within several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and prostate gland development. Located in collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; brain; immune system; ovary; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]

Tnc Products (5)

mRNA Protein Name
NM_001369211.1 NP_001356140.1 tenascin isoform 1 precursor
NM_001369212.1 NP_001356141.1 tenascin isoform 3 precursor
NM_001369213.1 NP_001356142.1 tenascin isoform 4
NM_001369214.1 NP_001356143.1 tenascin isoform 5 precursor
NM_011607.3 NP_035737.2 tenascin isoform 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within mesenchymal-epithelial cell signaling involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
18950615 MGI
involved in morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
18950615 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
9593587 MGI
involved in neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
9593587 MGI
acts upstream of or within peripheral nervous system axon regeneration IMP
IMP: Inferred from mutant phenotype
16262655 MGI
involved in peripheral nervous system axon regeneration IMP
IMP: Inferred from mutant phenotype
16262655 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19690384 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19690384 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19690384 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
18950615 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
10594729 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
7687262 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
23658023 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
8856503 MGI
located in interstitial matrix IDA
IDA: Inferred from direct assay
11767049 MGI
is active in perisynaptic extracellular matrix EXP
EXP: Inferred from Experiment
16452087 MGI
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
16452087 MGI
part of tenascin complex IPI
IPI: Inferred from physical interaction
14709716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tenascin

  • hexabrachion

Recombinant Tnc Proteins

Cat. No. Product Name Accession Purity
HY-P700002 Tenascin/Tnc Protein, Mouse (HEK293, His-Myc) Q80YX1-1 (G1884-N2099) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700834 Tenascin/Tnc protein, Mouse (HEK293, His) Q80YX1-1 (G23-S621) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700002A Tenascin/Tnc Protein, Mouse (HEK293, His-Myc, solution) Q80YX1-1 (G1884-N2099) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14783 TNC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17263 Tnc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148543 FC-99 Inhibitor / Unkown
HY-RS14848 TNNC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19041 Tnnc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23717 Tnc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnc NCBI NCBI:3371