Kdm6a - lysine (K)-specific demethylase 6A Gene

Also Known as Utx

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22289

Summary

Enables DNA binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and histone H3-K27 demethylation. Located in nucleus. Part of Histone Methyltransferase complex. Is expressed in several structures, including early conceptus; gonad; liver; lung; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system Cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast Cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm6a Products (13)

mRNA Protein Name
NM_001310444.2 NP_001297373.1 lysine-specific demethylase 6A isoform 2
NM_001403371.1 NP_001390300.1 lysine-specific demethylase 6A isoform 3
NM_001403372.1 NP_001390301.1 lysine-specific demethylase 6A isoform 4
NM_001403373.1 NP_001390302.1 lysine-specific demethylase 6A isoform 5
NM_001403374.1 NP_001390303.1 lysine-specific demethylase 6A isoform 6
NM_001403375.1 NP_001390304.1 lysine-specific demethylase 6A isoform 7
NM_001403376.1 NP_001390305.1 lysine-specific demethylase 6A isoform 8
NM_001403377.1 NP_001390306.1 lysine-specific demethylase 6A isoform 9
NM_001403378.1 NP_001390307.1 lysine-specific demethylase 6A isoform 10
NM_001403379.1 NP_001390308.1 lysine-specific demethylase 6A isoform 11
NM_001403380.1 NP_001390309.1 lysine-specific demethylase 6A isoform 12
NM_001403381.1 NP_001390310.1 lysine-specific demethylase 6A isoform 13
NM_009483.3 NP_033509.1 lysine-specific demethylase 6A isoform 1
Protein Preferred Names Protein Names

lysine-specific demethylase 6A

  • [histone H3]-trimethyl-L-lysine(27) demethylase 6A

  • histone demethylase UTX

  • ubiquitously transcribed TPR protein on the X chromosome

  • ubiquitously transcribed X chromosome tetratricopeptide repeat protein

  • ubiquitously transcribed tetratricopeptide repea

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15648B GSK-J4 99.67% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-138794 XL177A Inhibitor 99.60% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-15648A GSK-J2 Control 99.75% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.33% Unkown
HY-138794A (Rac)-XL177A Inhibitor / Unkown
HY-RS07222 KDM6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-138794G XL177A (GMP) Inhibitor / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS16705 Kdm6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23140 Kdm6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24089 Uty Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm6a NCBI NCBI:7403