Vdac2 - voltage-dependent anion channel 2 Gene

Also Known as Vdac6; mVDAC2; mVDAC6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22334

Summary

Predicted to enable several functions, including Cholesterol binding activity; phosphatidylcholine binding activity; and voltage-gated anion channel activity. Involved in negative regulation of intrinsic apoptotic signaling pathway and negative regulation of protein polymerization. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Vdac2 Products (1)

mRNA Protein Name
NM_011695.2 NP_035825.1 voltage-dependent anion-selective channel protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxysterol binding IMP
IMP: Inferred from mutant phenotype
34799735 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12881569 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
12881569 MGI
involved in negative regulation of protein polymerization IMP
IMP: Inferred from mutant phenotype
12881569 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
22561200 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
33087875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 2

  • VDAC-2

  • VDAC-6

  • outer mitochondrial membrane protein porin 2

  • voltage-dependent anion-selective channel protein 6

Vdac2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Vdac2 Q60930 Bak1 Mus musculus O08734
Anti Tag CoIP
12881569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15763 Erastin Inhibitor 99.91% Unkown
HY-128777 WEHI-9625 Inhibitor 99.46% Unkown
HY-172262 WEHI-3773 Ligand 99.89% Unkown
HY-181529 NCATS-SM0225 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdac2 NCBI NCBI:7417