Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

Also Known as Glk; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; 4833416M01Rik; 4833416M07Rik; 9530052P13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225028

About Map4k3

Chromosome 17: 80,887,941-81,035,914 reverse strand.GRCm39:CM001010.3

This gene has 8 transcripts (splice variants), 211 orthologues, 35 paralogues and is associated with 16 phenotypes. Ubiquitous expression in bladder adult (RPKM 16.8), limb E14.5 (RPKM 14.8) and 28 other tissues.

Summary

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to act upstream of or within phosphorylation. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map4k3 Products (2)

mRNA Protein Name
NM_001360278.1 NP_001347207.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 2
NM_001290345.1 NP_001277274.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21983831 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map4k3 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (14 - 272)

CNH

CNH: smart00036 (560 - 873)

  • 0
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  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 3

  • MAPK/ERK kinase kinase kinase 3

  • MEK kinase kinase 3

  • germinal center kinase-related protein kinase

Map4k3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Map4k3 Q99JP0 Prkcq Mus musculus Q02111
Anti Bait CoIP
21983831
Cross
Map4k3 Q99JP0 LCP2 Homo sapiens Q13094
Anti Tag CoIP
21983831
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-RS08077 MAP4K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08078 Map4k3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08079 Map4k3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k3 NCBI NCBI:8491