DLGAP4 - DLG associated protein 4 Gene

Also Known as DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22839

About DLGAP4

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,306,339-36,528,633 (from NCBI)

This gene has 15 transcripts (splice variants), 336 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 12.5), endometrium (RPKM 11.0) and 25 other tissues.

Summary

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as Other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DLGAP4 Products (14)

mRNA	Protein	Name
NM_001042486.4	NP_001035951.1	disks large-associated protein 4 isoform c
NM_001365621.2	NP_001352550.1	disks large-associated protein 4 isoform d
NM_001388257.1	NP_001375186.1	disks large-associated protein 4 isoform c
NM_001388260.1	NP_001375189.1	disks large-associated protein 4 isoform c
NM_001388262.1	NP_001375191.1	disks large-associated protein 4 isoform c
NM_001388265.1	NP_001375194.1	disks large-associated protein 4 isoform c
NM_001388268.1	NP_001375197.1	disks large-associated protein 4 isoform c
NM_001388271.1	NP_001375200.1	disks large-associated protein 4 isoform c
NM_001388274.1	NP_001375203.1	disks large-associated protein 4 isoform c
NM_001388275.1	NP_001375204.1	disks large-associated protein 4 isoform c
NM_001388277.1	NP_001375206.1	disks large-associated protein 4 isoform e
NM_001388278.1	NP_001375207.1	disks large-associated protein 4 isoform f
NM_014902.6	NP_055717.2	disks large-associated protein 4 isoform a
NM_183006.4	NP_892118.1	disks large-associated protein 4 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16275660	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP4 Protein Structure

GKAP

0
200
400
600
800
992 a.a.

Protein Preferred Names	Protein Names
disks large-associated protein 4	PSD-95/SAP90-binding protein 4

DLGAP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DLGAP4	Q9Y2H0	BIN1	Homo sapiens	O00499	Filter Binding	16275660
Intra	DLGAP4	Q9Y2H0	BIN1	Homo sapiens	O00499	Peptide Array	16275660
Intra	DLGAP4	Q9Y2H0	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03804	DLGAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DLGAP4	VGNC	VGNC:84728
Felis catus	DLGAP4	VGNC	VGNC:61516
Mus musculus	DLGAP4	MGD	MGI:2138865
Canis familiaris	DLGAP4	VGNC	VGNC:39982
Bos taurus	DLGAP4	VGNC	VGNC:28090
Rattus norvegicus	DLGAP4	RGD	RGD:708350
Others	DLGAP4	NCBI