KHDC4 - KH domain containing 4, pre-mRNA splicing factor Gene

Also Known as BLOM7; KIAA0907; SNORA80EHG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22889

About KHDC4

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,913,045-155,934,413 (from NCBI)

This gene has 10 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in lymph node (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splice site selection. Located in cytoplasm and nucleoplasm. Colocalizes with spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]

KHDC4 Products (1)

mRNA Protein Name
NM_014949.4 NP_055764.2 KH homology domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
19641227 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19641227 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splice site recognition IDA
IDA: Inferred from direct assay
19641227 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19641227 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19641227 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
19641227 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

KH homology domain-containing protein 4

  • brings lots of money 7

KHDC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KHDC4 Q7Z7F0 RBM39 Homo sapiens Q14498-3
Y2H Prey Pooling
25416956
Intra
KHDC4 Q7Z7F0 RBM39 Homo sapiens Q14498-3
Validated Y2H
25416956
Intra
KHDC4 Q7Z7F0 RBM39 Homo sapiens Q14498-3
Y2H Array
25416956
Intra
KHDC4 Q7Z7F0 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lip Cancer

  • Malignant Neoplasm Of Lip

  • Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower

  • Malignant Tumour Of Lip

  • Lip Neoplasms

  • Malignant Neoplasm Of Commissure Of Lip

  • Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower

  • Malignant Neoplasm Of Labial Commissure Of Lip

  • Malignant Neoplasm Of Lip, External

  • Malignant Neoplasm Of Lip, Inner Aspect

  • Malignant Neoplasm Of Lip, Vermilion Border

  • Malignant Neoplasm Of Lower Lip, Buccal Aspect

  • Malignant Neoplasm Of Lower Lip, Inner Aspect

  • Malignant Neoplasm Of Lower Lip, Mucosa

  • Malignant Neoplasm Of Lower Lip, Oral Aspect

  • Malignant Neoplasm Of Other Sites Of Lip

  • Malignant Neoplasm Of Vermilion Border Of Lip

  • Malignant Tumor Of Commissure Of Lip

  • Malignant Tumor Of Labial Mucosa

  • Malignant Tumor Of Lip

  • Malignant Tumor Of Lower Labial Mucosa

  • Malignant Tumor Of The Lip

  • Malignant Tumour Of Labial Commissure

  • Cancer Of Lip

  • Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip

  • Upper Lip Cancer

  • Lower Lip Cancer

  • Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip

  • Primary Malignant Neoplasm Of Vermilion Border Of Lip

  • Malignant Neoplasm Of Lipstick Area Of Upper Lip

  • Malignant Neoplasm Of Upper Lip Nos

  • Malignant Neoplasm Of Vermilion Border Of Upper Lip

  • Malignant Neoplasm Of Lipstick Area Of Lower Lip

  • Malignant Neoplasm Of Lower Lip Nos

  • Malignant Neoplasm Of Vermilion Border Of Lower Lip

  • Malignant Neoplasm Of Vermilion Border Nos

  • Malignant Neoplasm Of Buccal Aspect Of Upper Lip

  • Malignant Neoplasm Of Frenulum Of Upper Lip

  • Malignant Neoplasm Of Mucosa Of Upper Lip

  • Malignant Neoplasm Of Oral Aspect Of Upper Lip

  • Malignant Neoplasm Of Buccal Aspect Of Lower Lip

  • Malignant Neoplasm Of Frenulum Of Lower Lip

  • Malignant Neoplasm Of Mucosa Of Lower Lip

  • Malignant Neoplasm Of Oral Aspect Of Lower Lip

  • Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower

  • Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower

  • Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower

  • Primary Malignant Neoplasm Of Commissure Of Lip

  • Primary Malignant Neoplasm Of Lip

  • Malignant Neoplasm Of Lip, Unspecified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07236 KHDC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KHDC4 VGNC VGNC:63077
Macaca mulatta KHDC4 VGNC VGNC:73931
Canis familiaris KHDC4 VGNC VGNC:42354
Mus musculus KHDC4 MGD MGI:1921450
Bos taurus KHDC4 VGNC VGNC:30559
Rattus norvegicus KHDC4 RGD RGD:1565775
Others KHDC4 NCBI