Shb - src homology 2 domain-containing transforming protein B Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230126

Summary

Predicted to enable phosphotyrosine residue binding activity. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in brain; molar; and sensory organ. Orthologous to human SHB (SH2 domain containing adaptor protein B). [provided by Alliance of Genome Resources, Apr 2022]

Shb Products (1)

mRNA Protein Name
NM_001033306.1 NP_001028478.1 SH2 domain-containing adapter protein B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables signaling receptor complex adaptor activity IDA
IDA: Inferred from direct assay
8302579 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell proliferation IDA
IDA: Inferred from direct assay
11786382 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24645804 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
19223532 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15919073 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15919073 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
23528453 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
16971391 MGI
acts upstream of or within negative regulation of oocyte maturation IMP
IMP: Inferred from mutant phenotype
20585392 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
23528453 MGI
acts upstream of or within positive regulation of T-helper cell differentiation IMP
IMP: Inferred from mutant phenotype
24645804 MGI
acts upstream of or within positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23528453 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2 domain-containing adapter protein B

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0110 Gestodene Agonist 99.89% Unkown
HY-B0110R Gestodene (Standard) Agonist / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19360 Sulprostone Agonist ≥99.0% Unkown
HY-B0110S Gestodene-d6 Agonist / Unkown
HY-P5165 Maurotoxin Inhibitor / Unkown
HY-RS12854 SHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18456 Shb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24937 Shb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shb NCBI NCBI:6461