SHB - SH2 domain containing adaptor protein B Gene

Also Known as bA3J10.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6461

About SHB

Cytogenetic location: 9p13.1 Genomic coordinates (GRCh38): 9:37,915,898-38,069,227 (from NCBI)

This gene has 1 transcript (splice variant), 122 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in several processes, including angiogenesis; apoptotic process; and signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SHB Products (1)

mRNA Protein Name
NM_003028.3 NP_003019.2 SH2 domain-containing adapter protein B

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17112510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHB Protein Structure

SH2

SH2: SH2 domain (410 - 485)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing adapter protein B

  • SHB (Src homology 2 domain containing) adaptor protein B

SHB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHB Q15464 MET Homo sapiens P08581
FPS
24728074
Intra
SHB Q15464 KIT Homo sapiens P10721
FPS
24728074
Intra
SHB Q15464 ABL1 Homo sapiens P00519
Anti Bait CoIP
17112510
Intra
SHB Q15464 ABL1 Homo sapiens P00519
Pull Down
17112510
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sulfhemoglobinemia
Horner'S Syndrome

  • Horner Syndrome

  • Bernard-Horner Syndrome

  • Oculosympathetic Palsy

  • Bernard Horner Syndrome

  • Cervical Sympathetic Paralysis

  • Von Passow Syndrome

  • Cervical Sympathetic Dystrophy
Methemoglobinemia
Familial Isolated Hypoparathyroidism

  • Fih
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0110 Gestodene Agonist 99.89% Unkown
HY-B0110R Gestodene (Standard) Agonist / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19360 Sulprostone Agonist ≥99.0% Unkown
HY-B0110S Gestodene-d6 Agonist / Unkown
HY-P5165 Maurotoxin Inhibitor / Unkown
HY-RS12854 SHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18456 Shb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24937 Shb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SHB VGNC VGNC:46138
Bos taurus SHB VGNC VGNC:34588
Rattus norvegicus SHB RGD RGD:1565350
Mus musculus SHB MGD MGI:98294
Macaca mulatta SHB VGNC VGNC:82236
Others SHB NCBI