SHB - SH2 domain containing adaptor protein B Gene

Homo sapiens

Also known as bA3J10.2

Gene ID: 6461 | Gene type: protein coding

About SHB

Cytogenetic location: 9p13.1 Genomic coordinates (GRCh38): 9:37,915,898-38,069,227 (from NCBI)

This gene has 1 transcript (splice variant), 122 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in several processes, including angiogenesis; apoptotic process; and signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SHB Products(1)

mRNA	Protein	Name
NM_003028.3	NP_003019.2	SH2 domain-containing adapter protein B

SHB Protein Structure

SH2

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing adapter protein B

SHB (Src homology 2 domain containing) adaptor protein B

Related Diseases

Diseases

Alias

Sulfhemoglobinemia

Horner'S Syndrome

Horner Syndrome	Bernard-Horner Syndrome
Oculosympathetic Palsy	Bernard Horner Syndrome
Cervical Sympathetic Paralysis	Von Passow Syndrome
Cervical Sympathetic Dystrophy

Methemoglobinemia

Familial Isolated Hypoparathyroidism

Fih

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0110	Gestodene	Agonist	99.90%	Unkown
HY-B0110R	Gestodene (Standard)	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19360	Sulprostone	Agonist	≥99.0%	Unkown
HY-B0110S	Gestodene-d6	Agonist	/	Unkown
HY-P5165	Maurotoxin	Inhibitor	/	Unkown
HY-RS12854	SHB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SHB	VGNC	VGNC:46138
Bos taurus	SHB	VGNC	VGNC:34588
Rattus norvegicus	SHB	RGD	RGD:1565350
Mus musculus	SHB	MGD	MGI:98294
Macaca mulatta	SHB	VGNC	VGNC:82236
Others	SHB	NCBI

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