Gestodene (Standard)
Gestodene (Standard) (SHB 331 (Standard); WL 70 (Standard)) is the analytical standard of Gestodene (HY-B0110). This product is intended for research and analytical applications. Gestodene is an orally active synthetic progestogen compound of the 19-nortestosterone class. Gestodene binds with high affinity to the progesterone receptor, inhibits 5α-reductase, binds to androgen and aldosterone receptors, and inactivates CYP3A. Gestodene acts as a positive allosteric modulator of PAR1, enhances PAR1-mediated signaling pathways, and is capable of increasing the activation potency of PAR1-AP toward PAR1, thereby promoting ERK1/2 phosphorylation, receptor internalization, cell morphological changes, and human platelet aggregation. Gestodene and its A-ring reduced metabolites promote the proliferation, differentiation, and mineralization of neonatal rat osteoblasts. Gestodene itself has no binding capacity for estrogen receptors, and this osteogenic activity depends on intracellular metabolism to generate A-ring reduced products with estrogen-like agonistic activity. Gestodene is useful for research on diseases related to progesterone secretion and diseases related to thrombosis.
For research use only. We do not sell to patients.
- CAS No.: 60282-87-3
- Formula: C₂₁H₂₆O₂
- Molecular Weight:310.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-B0110
GestodeneSynthetic Progestogen -
HY-B0469
Medroxyprogesterone acetateProgesterone Receptor Agonist -
HY-B0084
DienogestProgesterone Receptor Agonist -
HY-N0437
ProgesteroneEndogenous Metabolite -
HY-B0521
AltrenogestProgesterone Receptor Agonist -
HY-13683
MifepristoneProgesterone Receptor Antagonist -
HY-B0141
EstradiolHuman Endogenous Metabolite -
HY-13636
FulvestrantEstrogen Receptor Antagonist -
HY-16950
4-HydroxytamoxifenEstrogen Receptor Modulator -
HY-B0469R
Medroxyprogesterone acetate (Standard) -
HY-B0257A
DydrogesteroneProgestogen -
HY-B0234
EstroneEndogenous Metabolite
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 60282-87-3
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Molecular Weight 310.43
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Formula C₂₁H₂₆O₂
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SMILES
CC[C@@]1([C@]2(O)C#C)[C@](C=C2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@@]3([H])CC4)([H])CC1
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Synonyms
SHB 331 (Standard); WL 70 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gestodene (Standard) Related Classifications
HY-B0110R Related Classifications
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Keywords
- Gestodene (Standard)
- 60282-87-3
- SHB 331 (Standard)
- WL 70 (Standard)
- Reference Standards
- Progesterone Receptor
- ERK
- Cytochrome P450
- Protease Activated Receptor (PAR)
- 5 alpha Reductase
- MMP
- Drug Intermediate
- T47D-A cells
- neonatal rat calvarial osteoblasts
- CYP3A
- MCF-7 breast cancer cells
- progesterone receptors
- HT29 cells
- PAR1-selective positive allosteric modulator
- 5α-reductase
- SHBG
- A2058 cells
- Inhibitor
- inhibitor
- inhibit