CLASP2 - cytoplasmic linker associated protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23122

About CLASP2

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,496,245-33,718,254 (from NCBI)

This gene has 27 transcripts (splice variants), 226 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues.

Summary

Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including microtubule Cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; cortical microtubule plus-end; and ruffle membrane. Colocalizes with focal adhesion; kinetochore; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CLASP2 Products (53)

mRNA Protein Name
NM_001207044.3 NP_001193973.1 CLIP-associating protein 2 isoform 2
NM_001365627.1 NP_001352556.1 CLIP-associating protein 2 isoform 3
NM_001365628.1 NP_001352557.1 CLIP-associating protein 2 isoform 4
NM_001365629.1 NP_001352558.1 CLIP-associating protein 2 isoform 5
NM_001365630.1 NP_001352559.1 CLIP-associating protein 2 isoform 6
NM_001365631.1 NP_001352560.1 CLIP-associating protein 2 isoform 7
NM_001365632.1 NP_001352561.1 CLIP-associating protein 2 isoform 8
NM_001365633.1 NP_001352562.1 CLIP-associating protein 2 isoform 9
NM_001365634.1 NP_001352563.1 CLIP-associating protein 2 isoform 10
NM_001375694.1 NP_001362623.1 CLIP-associating protein 2 isoform 11
NM_001375697.1 NP_001362626.1 CLIP-associating protein 2 isoform 12
NM_001375700.1 NP_001362629.1 CLIP-associating protein 2 isoform 13
NM_001375701.1 NP_001362630.1 CLIP-associating protein 2 isoform 14
NM_001375703.1 NP_001362632.1 CLIP-associating protein 2 isoform 16
NM_001375705.1 NP_001362634.1 CLIP-associating protein 2 isoform 15
NM_001375713.1 NP_001362642.1 CLIP-associating protein 2 isoform 17
NM_001375715.1 NP_001362644.1 CLIP-associating protein 2 isoform 18
NM_001375716.1 NP_001362645.1 CLIP-associating protein 2 isoform 19
NM_001375718.1 NP_001362647.1 CLIP-associating protein 2 isoform 20
NM_001375720.1 NP_001362649.1 CLIP-associating protein 2 isoform 21
NM_001400405.1 NP_001387334.1 CLIP-associating protein 2 isoform 22
NM_001400406.1 NP_001387335.1 CLIP-associating protein 2 isoform 23
NM_001400407.1 NP_001387336.1 CLIP-associating protein 2 isoform 24
NM_001400408.1 NP_001387337.1 CLIP-associating protein 2 isoform 25
NM_001400409.1 NP_001387338.1 CLIP-associating protein 2 isoform 26
NM_001400410.1 NP_001387339.1 CLIP-associating protein 2 isoform 27
NM_001400411.1 NP_001387340.1 CLIP-associating protein 2 isoform 28
NM_001400412.1 NP_001387341.1 CLIP-associating protein 2 isoform 29
NM_001400413.1 NP_001387342.1 CLIP-associating protein 2 isoform 30
NM_001400414.1 NP_001387343.1 CLIP-associating protein 2 isoform 31
NM_001400415.1 NP_001387344.1 CLIP-associating protein 2 isoform 32
NM_001400416.1 NP_001387345.1 CLIP-associating protein 2 isoform 33
NM_001400417.1 NP_001387346.1 CLIP-associating protein 2 isoform 33
NM_001400418.1 NP_001387347.1 CLIP-associating protein 2 isoform 34
NM_001400419.1 NP_001387348.1 CLIP-associating protein 2 isoform 35
NM_001400420.1 NP_001387349.1 CLIP-associating protein 2 isoform 36
NM_001400421.1 NP_001387350.1 CLIP-associating protein 2 isoform 37
NM_001400422.1 NP_001387351.1 CLIP-associating protein 2 isoform 38
NM_001400423.1 NP_001387352.1 CLIP-associating protein 2 isoform 39
NM_001400424.1 NP_001387353.1 CLIP-associating protein 2 isoform 40
NM_001400425.1 NP_001387354.1 CLIP-associating protein 2 isoform 41
NM_001400427.1 NP_001387356.1 CLIP-associating protein 2 isoform 42
NM_001400428.1 NP_001387357.1 CLIP-associating protein 2 isoform 43
NM_001400429.1 NP_001387358.1 CLIP-associating protein 2 isoform 44
NM_001400430.1 NP_001387359.1 CLIP-associating protein 2 isoform 45
NM_001400431.1 NP_001387360.1 CLIP-associating protein 2 isoform 46
NM_001400432.1 NP_001387361.1 CLIP-associating protein 2 isoform 47
NM_001400433.1 NP_001387362.1 CLIP-associating protein 2 isoform 48
NM_001400434.1 NP_001387363.1 CLIP-associating protein 2 isoform 49
NM_001400435.1 NP_001387364.1 CLIP-associating protein 2 isoform 50
NM_001400436.1 NP_001387365.1 CLIP-associating protein 2 isoform 51
NM_001400437.1 NP_001387366.1 CLIP-associating protein 2 isoform 52
NM_015097.3 NP_055912.2 CLIP-associating protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
24520051 GOA
enables dystroglycan binding IPI
IPI: Inferred from physical interaction
23940118 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
24520051 GOA
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
11290329 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11290329 GOA
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
24520051 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in exit from mitosis IMP
IMP: Inferred from mutant phenotype
16866869 GOA
involved in microtubule anchoring IMP
IMP: Inferred from mutant phenotype
17543864 GOA
involved in microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in microtubule nucleation IMP
IMP: Inferred from mutant phenotype
17543864 GOA
involved in microtubule organizing center organization IMP
IMP: Inferred from mutant phenotype
17543864 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
16866869 GOA
involved in negative regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in negative regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in negative regulation of wound healing, spreading of epidermal cells IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in platelet-derived growth factor receptor-beta signaling pathway IDA
IDA: Inferred from direct assay
24520051 GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
23940118 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in positive regulation of extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
24859005 GOA
involved in presynaptic cytoskeleton organization IDA
IDA: Inferred from direct assay
23035100 GOA
involved in presynaptic cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23035100 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23940118 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
24520051 GOA
involved in regulation of axon extension IDA
IDA: Inferred from direct assay
24520051 GOA
involved in regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
23940118 GOA
involved in regulation of gastrulation IMP
IMP: Inferred from mutant phenotype
23940118 GOA
involved in regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
24520051 GOA
involved in regulation of microtubule polymerization or depolymerization IMP
IMP: Inferred from mutant phenotype
11290329 GOA
involved in regulation of microtubule-based process IMP
IMP: Inferred from mutant phenotype
20937854 GOA
involved in vesicle targeting IMP
IMP: Inferred from mutant phenotype
24859005 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11290329 GOA
located in axonal growth cone IDA
IDA: Inferred from direct assay
24520051 GOA
located in basal cortex IDA
IDA: Inferred from direct assay
23940118 GOA
located in cell cortex IDA
IDA: Inferred from direct assay
17113391 GOA
located in cell leading edge IDA
IDA: Inferred from direct assay
24859005 GOA
located in cortical microtubule plus-end IDA
IDA: Inferred from direct assay
24520051 GOA
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
11290329 GOA
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
24859005 GOA
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23035100 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23035100 GOA
colocalizes with kinetochore IMP
IMP: Inferred from mutant phenotype
16866869 GOA
colocalizes with microtubule IDA
IDA: Inferred from direct assay
24859005 GOA
located in microtubule IDA
IDA: Inferred from direct assay
17543864 GOA
colocalizes with mitotic spindle IMP
IMP: Inferred from mutant phenotype
16866869 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20937854 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
20937854 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
17543864 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLASP2 Protein Structure

CLASP_N

CLASP_N: CLASP N terminal (67 - 203)

CLASP_N

CLASP_N: CLASP N terminal (322 - 538)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1514 a.a.
Protein Preferred Names Protein Names

CLIP-associating protein 2

  • CLIP-associating protein CLASP2

CLASP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLASP2 O75122 MAPRE1 Homo sapiens Q15691
Pull Down
19632184
Intra
CLASP2 O75122 YWHAE Homo sapiens P62258
Anti Tag CoIP
35271311
Intra
CLASP2 O75122 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross
CLASP2 O75122 Clip2 Rattus norvegicus O55156
Pull Down
11290329
Cross
CLASP2 O75122 Clip2 Rattus norvegicus O55156
Anti Tag CoIP
11290329
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0227 SHU 9119 99.83% Unkown
HY-P1208 PG-931 Agonist 99.60% Unkown
HY-RS02745 CLASP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLASP2 MGD MGI:1923749
Canis familiaris CLASP2 VGNC VGNC:39295
Macaca mulatta CLASP2 VGNC VGNC:84201
Bos taurus CLASP2 VGNC VGNC:27390
Felis catus CLASP2 VGNC VGNC:60917
Rattus norvegicus CLASP2 RGD RGD:619789
Others CLASP2 NCBI