2. Gene
  3. CLASP2 - cytoplasmic linker associated protein 2 Gene

CLASP2 - cytoplasmic linker associated protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 23122 | Gene type: protein coding

About CLASP2

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,496,245-33,718,254 (from NCBI)

This gene has 27 transcripts (splice variants), 226 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues.

Summary

Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including microtubule Cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; cortical microtubule plus-end; and ruffle membrane. Colocalizes with focal adhesion; kinetochore; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CLASP2 Products(53)

mRNA Protein Name
NM_001207044.3 NP_001193973.1 CLIP-associating protein 2 isoform 2
NM_001365627.1 NP_001352556.1 CLIP-associating protein 2 isoform 3
NM_001365628.1 NP_001352557.1 CLIP-associating protein 2 isoform 4
NM_001365629.1 NP_001352558.1 CLIP-associating protein 2 isoform 5
NM_001365630.1 NP_001352559.1 CLIP-associating protein 2 isoform 6
NM_001365631.1 NP_001352560.1 CLIP-associating protein 2 isoform 7
NM_001365632.1 NP_001352561.1 CLIP-associating protein 2 isoform 8
NM_001365633.1 NP_001352562.1 CLIP-associating protein 2 isoform 9
NM_001365634.1 NP_001352563.1 CLIP-associating protein 2 isoform 10
NM_001375694.1 NP_001362623.1 CLIP-associating protein 2 isoform 11
NM_001375697.1 NP_001362626.1 CLIP-associating protein 2 isoform 12
NM_001375700.1 NP_001362629.1 CLIP-associating protein 2 isoform 13
NM_001375701.1 NP_001362630.1 CLIP-associating protein 2 isoform 14
NM_001375703.1 NP_001362632.1 CLIP-associating protein 2 isoform 16
NM_001375705.1 NP_001362634.1 CLIP-associating protein 2 isoform 15
NM_001375713.1 NP_001362642.1 CLIP-associating protein 2 isoform 17
NM_001375715.1 NP_001362644.1 CLIP-associating protein 2 isoform 18
NM_001375716.1 NP_001362645.1 CLIP-associating protein 2 isoform 19
NM_001375718.1 NP_001362647.1 CLIP-associating protein 2 isoform 20
NM_001375720.1 NP_001362649.1 CLIP-associating protein 2 isoform 21
NM_001400405.1 NP_001387334.1 CLIP-associating protein 2 isoform 22
NM_001400406.1 NP_001387335.1 CLIP-associating protein 2 isoform 23
NM_001400407.1 NP_001387336.1 CLIP-associating protein 2 isoform 24
NM_001400408.1 NP_001387337.1 CLIP-associating protein 2 isoform 25
NM_001400409.1 NP_001387338.1 CLIP-associating protein 2 isoform 26
NM_001400410.1 NP_001387339.1 CLIP-associating protein 2 isoform 27
NM_001400411.1 NP_001387340.1 CLIP-associating protein 2 isoform 28
NM_001400412.1 NP_001387341.1 CLIP-associating protein 2 isoform 29
NM_001400413.1 NP_001387342.1 CLIP-associating protein 2 isoform 30
NM_001400414.1 NP_001387343.1 CLIP-associating protein 2 isoform 31
NM_001400415.1 NP_001387344.1 CLIP-associating protein 2 isoform 32
NM_001400416.1 NP_001387345.1 CLIP-associating protein 2 isoform 33
NM_001400417.1 NP_001387346.1 CLIP-associating protein 2 isoform 33
NM_001400418.1 NP_001387347.1 CLIP-associating protein 2 isoform 34
NM_001400419.1 NP_001387348.1 CLIP-associating protein 2 isoform 35
NM_001400420.1 NP_001387349.1 CLIP-associating protein 2 isoform 36
NM_001400421.1 NP_001387350.1 CLIP-associating protein 2 isoform 37
NM_001400422.1 NP_001387351.1 CLIP-associating protein 2 isoform 38
NM_001400423.1 NP_001387352.1 CLIP-associating protein 2 isoform 39
NM_001400424.1 NP_001387353.1 CLIP-associating protein 2 isoform 40
NM_001400425.1 NP_001387354.1 CLIP-associating protein 2 isoform 41
NM_001400427.1 NP_001387356.1 CLIP-associating protein 2 isoform 42
NM_001400428.1 NP_001387357.1 CLIP-associating protein 2 isoform 43
NM_001400429.1 NP_001387358.1 CLIP-associating protein 2 isoform 44
NM_001400430.1 NP_001387359.1 CLIP-associating protein 2 isoform 45
NM_001400431.1 NP_001387360.1 CLIP-associating protein 2 isoform 46
NM_001400432.1 NP_001387361.1 CLIP-associating protein 2 isoform 47
NM_001400433.1 NP_001387362.1 CLIP-associating protein 2 isoform 48
NM_001400434.1 NP_001387363.1 CLIP-associating protein 2 isoform 49
NM_001400435.1 NP_001387364.1 CLIP-associating protein 2 isoform 50
NM_001400436.1 NP_001387365.1 CLIP-associating protein 2 isoform 51
NM_001400437.1 NP_001387366.1 CLIP-associating protein 2 isoform 52
NM_015097.3 NP_055912.2 CLIP-associating protein 2 isoform 1

CLASP2 Protein Structure

CLASP_N

CLASP_N: CLASP N terminal (67 - 203)

CLASP_N

CLASP_N: CLASP N terminal (322 - 538)

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  • 1514 a.a.
Protein Preferred Names Protein Names

CLIP-associating protein 2

CLIP-associating protein CLASP2

Related Diseases

Diseases Alias
Lissencephaly 1

LIS1

Classic Lissencephaly

Ils

Subcortical Laminar Heterotopia

Lissencephaly Due To Lis1 Mutation

Lissencephaly Sequence, Isolated

Lissencephaly, Classic

Pafah1b1-Related Lissencephaly

Classical Lissencephaly

Lissencephaly Type 1

Lissencephaly-1

Subcortical Band Heterotopia

Double Cortex

Lissencephaly Classic

Lissencephaly Sequence Isolated

Isolated Lissencephaly Sequence

Type 1 Lissencephaly

Lissencephaly Syndrome Type 1

SBH

Sclh

Lissencephaly, Type 1

Type I Lissencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0227 SHU 9119 99.95% Unkown
HY-RS02745 CLASP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLASP2 MGD MGI:1923749
Canis familiaris CLASP2 VGNC VGNC:39295
Macaca mulatta CLASP2 VGNC VGNC:84201
Bos taurus CLASP2 VGNC VGNC:27390
Felis catus CLASP2 VGNC VGNC:60917
Rattus norvegicus CLASP2 RGD RGD:619789