GPATCH8 - G-patch domain containing 8 Gene

Also Known as GPATC8; KIAA0553

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23131

About GPATCH8

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,395,281-44,503,406 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 2.5), ovary (RPKM 2.5) and 25 other tissues.

Summary

The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

GPATCH8 Products (6)

mRNA Protein Name
NM_001002909.4 NP_001002909.1 G patch domain-containing protein 8 isoform 1
NM_001304939.2 NP_001291868.1 G patch domain-containing protein 8 isoform 2
NM_001304940.2 NP_001291869.1 G patch domain-containing protein 8 isoform 3
NM_001304941.2 NP_001291870.1 G patch domain-containing protein 8 isoform 3
NM_001304942.2 NP_001291871.1 G patch domain-containing protein 8 isoform 3
NM_001304943.2 NP_001291872.1 G patch domain-containing protein 8 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPATCH8 Protein Structure

G-patch

G-patch: G-patch domain (41 - 82)

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (136 - 163)

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  • 1502 a.a.
Protein Preferred Names Protein Names

G patch domain-containing protein 8

GPATCH8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
GPATCH8 Q9UKJ3 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperuricemia

  • Blood Urate Raized

  • Uricacidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05621 GPATCH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPATCH8 VGNC VGNC:29520
Rattus norvegicus GPATCH8 RGD RGD:1596463
Macaca mulatta GPATCH8 VGNC VGNC:73026
Canis familiaris GPATCH8 VGNC VGNC:41369
Mus musculus GPATCH8 MGD MGI:1918667
Felis catus GPATCH8 VGNC VGNC:99071
Others GPATCH8 NCBI