Mark4 - MAP/microtubule affinity regulating kinase 4 Gene

Also Known as Markl1; 2410090P21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232944

Summary

Predicted to enable protein kinase activity and tubulin binding activity. Predicted to be involved in several processes, including positive regulation of cilium assembly; positive regulation of protein localization to centrosome; and regulation of centrosome cycle. Predicted to act upstream of or within cell division; cell projection organization; and phosphorylation. Predicted to be located in several cellular components, including dendrite; microtubule organizing center; and midbody. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm. Orthologous to human MARK4 (microtubule affinity regulating kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Mark4 Products (2)

mRNA Protein Name
NM_001368427.1 NP_001355356.1 MAP/microtubule affinity-regulating kinase 4 isoform 2
NM_172279.2 NP_758483.1 MAP/microtubule affinity-regulating kinase 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal anchor activity IDA
IDA: Inferred from direct assay
28656979 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
28656979 MGI
Cellular Component GO Annotation Evidence References Source
is active in microtubule organizing center IDA
IDA: Inferred from direct assay
28656979 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP/microtubule affinity-regulating kinase 4

  • MAP/microtubule affinity-regulating kinase 4L

  • MARK4 serine/threonine protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139604 PCC0208017 99.52% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-114317 MARK4 inhibitor 1 98.29% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-154986 MARK4 inhibitor 2 Inhibitor 99.60% Unkown
HY-154987 MARK4 inhibitor 3 98.23% Unkown
HY-154988 MARK4 inhibitor 4 99.23% Unkown
HY-RS08152 MARK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18182 Mark4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24656 Mark4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mark4 NCBI NCBI:57787