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Ffar2 - free fatty acid receptor 2 Gene

Also Known as Gpr43; GPCR43

Species: Mus musculus

Gene Type: protein coding

Gene ID: 233079

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; positive regulation of acute inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Predicted to be located in cell projection and plasma membrane. Is expressed in pancreas; pancreas epithelium; superior cervical ganglion; and testis. Orthologous to human FFAR2 (Free Fatty Acid Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ffar2 Products (5)

mRNA	Protein	Name
NM_001168509.1	NP_001161981.1	free fatty acid receptor 2
NM_001168510.1	NP_001161982.1	free fatty acid receptor 2
NM_001168511.1	NP_001161983.1	free fatty acid receptor 2
NM_001168512.1	NP_001161984.1	free fatty acid receptor 2
NM_146187.4	NP_666299.1	free fatty acid receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	23589301	MGI
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	23665276	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23589301	MGI
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	25581519	MGI
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	23589301	MGI
involved in cellular response to fatty acid	IMP IMP: Inferred from mutant phenotype	16123168	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	16123168	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	23589301	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22190648	MGI
involved in leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	19865172	MGI
involved in ligand-gated ion channel signaling pathway	IDA IDA: Inferred from direct assay	26075576	MGI
involved in lipid storage	IDA IDA: Inferred from direct assay	23589301	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	16123168	MGI
involved in mucosal immune response	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in negative regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	25581519	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	26075576	MGI
involved in positive regulation of acute inflammatory response to non-antigenic stimulus	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	26075576	MGI
involved in regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	19865172	MGI
involved in regulation of peptide hormone secretion	IDA IDA: Inferred from direct assay	23589301	MGI
involved in regulation of peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	22190648	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	26075576	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
free fatty acid receptor 2	G protein-coupled receptor 43 leukocyte-specific STAT-induced GPCR

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182729	FFA2 agonist-2	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ffar2	NCBI	NCBI:2867