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CLASP1 - cytoplasmic linker associated protein 1 Gene

Also Known as MAST1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23332

About CLASP1

Cytogenetic location: 2q14.2-q14.3 Genomic coordinates (GRCh38): 2:121,337,776-121,649,462 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues.

Summary

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

CLASP1 Products (8)

mRNA	Protein	Name
NM_001142273.2	NP_001135745.1	CLIP-associating protein 1 isoform 2
NM_001142274.2	NP_001135746.1	CLIP-associating protein 1 isoform 3
NM_001207051.2	NP_001193980.1	CLIP-associating protein 1 isoform 4
NM_001378003.1	NP_001364932.1	CLIP-associating protein 1 isoform 5
NM_001378004.1	NP_001364933.1	CLIP-associating protein 1 isoform 6
NM_001378005.1	NP_001364934.1	CLIP-associating protein 1 isoform 7
NM_001395891.1	NP_001382820.1	CLIP-associating protein 1 isoform 8
NM_015282.3	NP_056097.1	CLIP-associating protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dystroglycan binding	IPI IPI: Inferred from physical interaction	23940118	GOA
enables kinetochore binding	IMP IMP: Inferred from mutant phenotype	12837247	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11290329	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	12837247	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	12837247	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11290329	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
acts upstream of or within cell division	IDA IDA: Inferred from direct assay	21822276	GOA
involved in establishment of mitotic spindle localization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
acts upstream of or within establishment of spindle orientation	IDA IDA: Inferred from direct assay	21822276	GOA
acts upstream of or within establishment of spindle orientation	IGI IGI: Inferred from genetic interaction	21822276	GOA
acts upstream of or within establishment of spindle orientation	IMP IMP: Inferred from mutant phenotype	21822276	GOA
involved in exit from mitosis	IMP IMP: Inferred from mutant phenotype	16866869	GOA
involved in microtubule anchoring	IMP IMP: Inferred from mutant phenotype	17543864	GOA
involved in microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	12837247	GOA
involved in microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	15631994	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in microtubule nucleation	IMP IMP: Inferred from mutant phenotype	17543864	GOA
involved in microtubule organizing center organization	IMP IMP: Inferred from mutant phenotype	17543864	GOA
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	16866869	GOA
involved in negative regulation of microtubule depolymerization	IGI IGI: Inferred from genetic interaction	15631994	GOA
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	16866869	GOA
involved in negative regulation of microtubule polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	12837247	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in negative regulation of wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI IGI: Inferred from genetic interaction	23940118	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in positive regulation of extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	23940118	GOA
involved in vesicle targeting	IMP IMP: Inferred from mutant phenotype	24859005	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15631994	GOA
located in basal cortex	IDA IDA: Inferred from direct assay	23940118	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	17113391	GOA
located in centrosomal corona	IDA IDA: Inferred from direct assay	16914514	GOA
located in centrosome	IDA IDA: Inferred from direct assay	12837247	GOA
located in cortical microtubule cytoskeleton	IDA IDA: Inferred from direct assay	12837247	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	11290329	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	24859005	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	12837247	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	12837247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLASP1 Protein Structure

CLASP_N

0
300
600
900
1200
1538 a.a.

Protein Preferred Names	Protein Names
CLIP-associating protein 1	multiple asters 1

CLASP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLASP1	Q7Z460	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	CLASP1	Q7Z460	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CLASP1	Q7Z460	SPAG5	Homo sapiens	Q96R06	Anti Bait CoIP	20852589
Intra	CLASP1	Q7Z460	SPAG5	Homo sapiens	Q96R06	Anti Tag CoIP	20852589
Intra	CLASP1	Q7Z460	KIF1B	Homo sapiens	O60333	Anti Tag CoIP	20852589
Intra	CLASP1	Q7Z460	KIF1B	Homo sapiens	O60333	Anti Bait CoIP	20852589
Cross	CLASP1	Q7Z460	Clip2	Rattus norvegicus	O55156	Anti Tag CoIP	11290329
Cross	CLASP1	Q7Z460	Clip2	Rattus norvegicus	O55156	Pull Down	11290329
Cross	CLASP1	Q7Z460	Clip1	Rattus norvegicus	Q9JK25	Anti Tag CoIP	11290329

Cross: Cross-species interaction Intra: Intraspecies interaction

CLASP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82388	CLASP1 Antibody (YA2133)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Taybi-Linder Syndrome Brachymelic Primordial Dwarfism Cephaloskeletal Dysplasia Low-Birth-Weight Dwarfism With Skeletal Dysplasia Microcephalic Osteodysplastic Primordial Dwarfism Type I Osteodysplastic Primordial Dwarfism Type I Primordial Microcephalic Dwarfism, Crachami Type Osteodysplastic Primordial Dwarfism, Type 1 MOPD1 Mopd I Mopd Osteodysplastic Primordial Dwarfism, Type I Tals Microcephalic Osteodysplastic Primordial Dwarfism Type 1 Mopd 1 Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3 Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii Mopd Types I And Iii Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type Primordial Microcephalic Dwarfism Crachami Type Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Lowry-Wood Syndrome	LWS Epiphyseal Dysplasia, Multiple, With Microcephaly And Retinal Dystrophy Lowry Wood Syndrome Epiphyseal Dysplasia, Microcephaly And Nystagmus Epiphyseal Dysplasia-Microcephaly-Nystagmus Syndrome Dysplasia, Epiphyseal, Microcephaly, Nystagmus
Spondyloepiphyseal Dysplasia Congenita	SEDC Sed Congenita Spondyloepiphyseal Dysplasia, Congenital Type Late Spondyloepiphyseal Dysplasia Sed, Congenital Type Congenital Spondyloepiphyseal Dysplasia Spranger-Wiedemann Disease Spondyloepiphyseal Dysplasia Congenital Type Dysplasia, Spondyloepiphyseal, Congenita Spondyloepiphyseal Dysplasia, Congenita Spondyloepiphyseal Dysplasia Tarda, X-Linked
Roifman Syndrome	RFMN Spondyloepiphyseal Dysplasia, Retinal Dystrophy, And Antibody Deficiency Spondyloepiphseal Dysplasia, Retinal Dystrophy And Antibody Deficiency Spondyloepiphyseal Dysplasia-Retinal Dystrophy-Immunodeficiency Syndrome
Balantidiasis	Balantidiosis Human Balantidiasis B Coli Infection Balantidium Coli Infection Large-Intestinal Infection With Balantidium Coli Ciliary Dysentery
Theileriasis	Theileriosis Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS02744	CLASP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLASP1	VGNC	VGNC:27389
Canis familiaris	CLASP1	VGNC	VGNC:39294
Mus musculus	CLASP1	MGD	MGI:1923957
Macaca mulatta	CLASP1	VGNC	VGNC:71193
Rattus norvegicus	CLASP1	RGD	RGD:1310970
Felis catus	CLASP1	VGNC	VGNC:60916
Others	CLASP1	NCBI