CLASP1 - cytoplasmic linker associated protein 1 Gene

Homo sapiens

Also known as MAST1

Gene ID: 23332 | Gene type: protein coding

About CLASP1

Cytogenetic location: 2q14.2-q14.3 Genomic coordinates (GRCh38): 2:121,337,776-121,649,462 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues.

Summary

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

CLASP1 Products(8)

mRNA	Protein	Name
NM_001142273.2	NP_001135745.1	CLIP-associating protein 1 isoform 2
NM_001142274.2	NP_001135746.1	CLIP-associating protein 1 isoform 3
NM_001207051.2	NP_001193980.1	CLIP-associating protein 1 isoform 4
NM_001378003.1	NP_001364932.1	CLIP-associating protein 1 isoform 5
NM_001378004.1	NP_001364933.1	CLIP-associating protein 1 isoform 6
NM_001378005.1	NP_001364934.1	CLIP-associating protein 1 isoform 7
NM_001395891.1	NP_001382820.1	CLIP-associating protein 1 isoform 8
NM_015282.3	NP_056097.1	CLIP-associating protein 1 isoform 1

CLASP1 Protein Structure

CLASP_N

0
300
600
900
1200
1538 a.a.

Protein Preferred Names

Protein Names

CLIP-associating protein 1

multiple asters 1

Related Diseases

Diseases

Alias

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome	Brachymelic Primordial Dwarfism
Cephaloskeletal Dysplasia	Low-Birth-Weight Dwarfism With Skeletal Dysplasia
Microcephalic Osteodysplastic Primordial Dwarfism Type I	Osteodysplastic Primordial Dwarfism Type I
Primordial Microcephalic Dwarfism, Crachami Type	Osteodysplastic Primordial Dwarfism, Type 1
MOPD1	Mopd I
Mopd	Osteodysplastic Primordial Dwarfism, Type I
Tals	Microcephalic Osteodysplastic Primordial Dwarfism Type 1
Mopd 1	Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii	Mopd Types I And Iii
Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type	Primordial Microcephalic Dwarfism Crachami Type
Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Lowry-Wood Syndrome

LWS	Epiphyseal Dysplasia, Multiple, With Microcephaly And Retinal Dystrophy
Lowry Wood Syndrome	Epiphyseal Dysplasia, Microcephaly And Nystagmus
Epiphyseal Dysplasia-Microcephaly-Nystagmus Syndrome	Dysplasia, Epiphyseal, Microcephaly, Nystagmus

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Roifman Syndrome

RFMN	Spondyloepiphyseal Dysplasia, Retinal Dystrophy, And Antibody Deficiency
Spondyloepiphseal Dysplasia, Retinal Dystrophy And Antibody Deficiency	Spondyloepiphyseal Dysplasia-Retinal Dystrophy-Immunodeficiency Syndrome

Balantidiasis

Balantidiosis	Human Balantidiasis
B Coli Infection	Balantidium Coli Infection
Large-Intestinal Infection With Balantidium Coli	Ciliary Dysentery

Theileriasis

Theileriosis

Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02744	CLASP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLASP1	VGNC	VGNC:27389
Canis familiaris	CLASP1	VGNC	VGNC:39294
Mus musculus	CLASP1	MGD	MGI:1923957
Macaca mulatta	CLASP1	VGNC	VGNC:71193
Rattus norvegicus	CLASP1	RGD	RGD:1310970
Felis catus	CLASP1	VGNC	VGNC:60916

Name
Email *

	Sorry, but the email address you supplied was invalid.