ZNF281 - zinc finger protein 281 Gene

Also Known as GZP1; ZBP99; ZBP-99; ZNP-99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23528

About ZNF281

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,404,951-200,410,036 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF281 Products (3)

mRNA Protein Name
NM_001281293.2 NP_001268222.1 zinc finger protein 281 isoform 1
NM_001281294.2 NP_001268223.1 zinc finger protein 281 isoform 2
NM_012482.5 NP_036614.1 zinc finger protein 281 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10448078 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10448078 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10448078 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17314511 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10405178 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
10448078 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12771217 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10448078 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
12771217 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10448078 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10448078 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10405178 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10448078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF281 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (275 - 298)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (332 - 355)

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  • 895 a.a.
Protein Preferred Names Protein Names

zinc finger protein 281

  • GC-box-binding zinc finger protein 1

ZNF281 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF281 Q9Y2X9 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ZNF281 Q9Y2X9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ZNF281 Q9Y2X9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ZNF281 Q9Y2X9 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ZNF281 Q9Y2X9 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
ZNF281 Q9Y2X9 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183629 ZNF281-IN-1 / Unkown
HY-RS16120 ZNF281 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZNF281 RGD RGD:1305139
Mus musculus ZNF281 MGD MGI:3029290
Macaca mulatta ZNF281 VGNC VGNC:100192
Others ZNF281 NCBI