Sik2 - salt inducible kinase 2 Gene

Also Known as Snf1lk2; G630080D20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 235344

About Sik2

Chromosome 9: 50,804,101-50,920,373 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 231 orthologues, 19 paralogues and is associated with 21 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 3.6) and 24 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and regulation of Insulin Receptor signaling pathway. Acts upstream of or within Insulin Receptor signaling pathway and protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sik2 Products (3)

mRNA	Protein	Name
NM_001405015.1	NP_001391944.1	serine/threonine-protein kinase SIK2 isoform 3
NM_178710.4	NP_848825.2	serine/threonine-protein kinase SIK2 isoform 1
NM_001405014.1	NP_001391943.1	serine/threonine-protein kinase SIK2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12624099	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12624099	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24561619	MGI
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	21084751	MGI
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	21084751	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12624099	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	12624099	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12624099	MGI
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	21084751	MGI
involved in negative regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	21084751	MGI
involved in negative regulation of transcription from RNA polymerase II promoter by glucose	IDA IDA: Inferred from direct assay	21084751	MGI
involved in negative regulation of transcription from RNA polymerase II promoter by glucose	IMP IMP: Inferred from mutant phenotype	21084751	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12624099	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12624099	MGI
involved in regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	12624099	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12624099	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12624099	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sik2 Protein Structure

STKc_SIK

UBA_SIK2

0
200
400
600
800
931 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase SIK2	SIK-2 SNF1-like kinase 2 salt induceable kinase 2 salt-inducible protein kinase 2 serine/threonine-protein kinase SNF1-like kinase 2

Sik2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Sik2	Q8CFH6	Cdk5r1	Mus musculus	P61809	Protein Kinase Assay	24561619

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15776	HG-9-91-01	Inhibitor	99.77%	Unkown
HY-120856	ARN-3236	Inhibitor	99.66%	Unkown
HY-120877	MRT199665	Inhibitor	99.85%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148062	RSS0680		99.85%	Unkown
HY-139253	MRIA9	Inhibitor	98.88%	Unkown
HY-175479	GLPG4970	Inhibitor	99.60%	Unkown
HY-163743	SIC-19	Inhibitor	98.00%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-173191	SK-124	Inhibitor	95.0%	Unkown
HY-171591	SIK2-IN-4	Inhibitor	99.06%	Unkown
HY-164534	SIK2/3-IN-2	Inhibitor	/	Unkown
HY-170237	SIK2/3-IN-1	Inhibitor	/	Unkown
HY-182804	SIK2/3-IN-3	Inhibitor	/	Unkown
HY-184954	SIK-IN-6	Inhibitor	/	Unkown
HY-171590	SIK2-IN-3	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sik2	NCBI	NCBI:23235