Sik2 - salt inducible kinase 2 Gene

Mus musculus

Also known as Snf1lk2; G630080D20Rik

Gene ID: 235344 | Gene type: protein coding

About Sik2

Chromosome 9: 50,804,101-50,920,373 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 231 orthologues, 19 paralogues and is associated with 21 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 3.6) and 24 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and regulation of Insulin Receptor signaling pathway. Acts upstream of or within Insulin Receptor signaling pathway and protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sik2 Products(3)

mRNA	Protein	Name
NM_001405015.1	NP_001391944.1	serine/threonine-protein kinase SIK2 isoform 3
NM_178710.4	NP_848825.2	serine/threonine-protein kinase SIK2 isoform 1
NM_001405014.1	NP_001391943.1	serine/threonine-protein kinase SIK2 isoform 2

Sik2 Protein Structure

STKc_SIK

UBA_SIK2

0
200
400
600
800
931 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase SIK2

SIK-2	SNF1-like kinase 2
salt induceable kinase 2	salt-inducible protein kinase 2
serine/threonine-protein kinase SNF1-like kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120856	ARN-3236	Inhibitor	98.60%	Unkown
HY-120877	MRT199665	Inhibitor	99.92%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-139253	MRIA9	Inhibitor	98.34%	Unkown
HY-157442	GLPG3312	Inhibitor	98.25%	Unkown
HY-148061	DB1113		99.28%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sik2	NCBI	NCBI:23235

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