Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

Also Known as ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235587

About Parp3

Chromosome 9: 106,347,521-106,354,148 reverse strand.GRCm39:CM001002.3

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in subcutaneous fat pad adult (RPKM 25.), bladder adult (RPKM 19.6) and 18 other tissues.

Summary

Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Parp3 Products (2)

mRNA Protein Name
NM_001311150.1 NP_001298079.1 protein mono-ADP-ribosyltransferase PARP3 isoform 1
NM_145619.3 NP_663594.2 protein mono-ADP-ribosyltransferase PARP3 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within double-strand break repair IGI
IGI: Inferred from genetic interaction
21270334 MGI
involved in negative regulation of isotype switching IMP
IMP: Inferred from mutant phenotype
26000965 MGI
Cellular Component GO Annotation Evidence References Source
located in site of double-strand break IDA
IDA: Inferred from direct assay
21270334 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp3 Protein Structure

WGR

WGR: cl01581 (55 - 153)

parp_like

parp_like: cd01437 (175 - 526)

  • 0
  • 100
  • 200
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  • 500
  • 528 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP3

  • A DP-ribosyltransferase (NAD+

  • poly (ADP-ribose polymerase)-like 3

  • ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3

  • ADP-ribosyltransferase diphtheria toxin-like 3

  • DNA ADP-ribosyltransferase PARP3

  • NAD(+) ADP-ribosyltransferase 3

  • NAD+ ADP-ribosyltransferase 3

  • Poly[ADP-ribose] synthetase-3

  • poly [ADP-ribose] polymerase 3

  • poly[ADP-ribose] synthase 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1
HY-13536 AZD-2461 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-100225 ME0328 Inhibitor 99.64% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-178032 PARP1-IN-44 Inhibitor / Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp3 NCBI NCBI:10039