Nr0b2 - nuclear receptor subfamily 0, group B, member 2 Gene

Also Known as SHP; Shp1; SHP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23957

Summary

This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded Orphan Receptor lacks a DNA binding domain but modulates gene expression by interacting with Other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein Cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]

Nr0b2 Products (1)

mRNA Protein Name
NM_011850.3 NP_035980.1 nuclear receptor subfamily 0 group B member 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20375098 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25212631 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
25212631 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 0 group B member 2

  • orphan nuclear receptor SHP

  • small heterodimer partner

Nr0b2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nr0b2 Q62227 Traf6 Mus musculus P70196
Confocal
21725320
Intra
Nr0b2 Q62227 Traf6 Mus musculus P70196
Anti Bait CoIP
21725320
Intra
Nr0b2 Q62227 Rela Mus musculus Q04207
Anti Bait CoIP
21725320
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09526 NR0B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21668 Nr0b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28186 Nr0b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr0b2 NCBI NCBI:8431