G6pd - glucose-6-phosphate dehydrogenase Gene

Also Known as G6pdx

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24377

Summary

Enables NADP binding activity; glucose binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in cytosol and nucleus. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; obesity; and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

G6pd Products (1)

mRNA Protein Name
NM_017006.2 NP_058702.1 glucose-6-phosphate 1-dehydrogenase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables D-glucose binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables D-glucose binding IMP
IMP: Inferred from mutant phenotype
16325866 RGD
enables NADP binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables NADP binding IMP
IMP: Inferred from mutant phenotype
16325866 RGD
enables carbohydrate binding IDA
IDA: Inferred from direct assay
2843500 RGD
enables glucose-6-phosphate dehydrogenase activity IDA
IDA: Inferred from direct assay
1834654 RGD
enables glucose-6-phosphate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
16325866 RGD
Biological Process GO Annotation Evidence References Source
involved in glucose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
involved in glucose 6-phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
16325866 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
24190878 RGD
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
24190878 RGD
involved in pentose-phosphate shunt IDA
IDA: Inferred from direct assay
2843500 RGD
involved in pentose-phosphate shunt, oxidative branch IMP
IMP: Inferred from mutant phenotype
9794092 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
23071515 RGD
involved in regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
12414804 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
18488910 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
19076169 RGD
involved in response to iron(III) ion IEP
IEP: Inferred from expression pattern
24599681 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17250641 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucose-6-phosphate 1-dehydrogenase

  • glucose-6-phosphate dehydrogenase X-linked

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-125863 Glucose-6-phosphate dehydrogenase, Microorganism / Phase 3
HY-N0120A Polydatin 99.50% Phase 2
HY-106328 Fluasterone Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W010342 6-Aminonicotinamide 99.95% Unkown
HY-W107464 G6PDi-1 99.53% Unkown
HY-16438 RRx-001 99.79% Yes
HY-123962 G6PD activator AG1 99.54% Unkown
HY-W017960 Diludine Activator 99.71% Unkown
HY-125863C Glucose-6-phosphate dehydrogenase, Bacillus sp. / Unkown
HY-N0120AR Polydatin (Standard) 98.40% Unkown
HY-W587796 6-Phosphoglucono-δ-lactone 99.0% Unkown
HY-RS05194 G6PD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125863B Glucose 6-phosphate dehydrogenase (yeast, recombinant) / Unkown
HY-W248922 2,6-Dibromo-4-(hydroxymethyl)phenol Inhibitor 99.87% Unkown
HY-125863A Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) / Unkown
HY-182002 Apoptosis inducer 61 / Unkown
HY-RS15375 UBL4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W017960R Diludine (Standard) Activator / Unkown
HY-136783 G6PD-IN-2 Inhibitor / Unkown
HY-RS22997 G6pd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens G6pd NCBI NCBI:2539