Lpl - lipoprotein lipase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24539

Summary

Enables lipoprotein Lipase activity and triglyceride binding activity. Involved in several processes, including negative regulation of cellular response to Insulin stimulus; response to cold; and triglyceride biosynthetic process. Located in extracellular space. Used to study abdominal obesity-metabolic syndrome 1; familial hyperlipidemia; non-alcoholic fatty liver disease; and obesity. Biomarker of end stage renal disease; focal segmental glomerulosclerosis; non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Lpl Products (1)

mRNA Protein Name
NM_012598.2 NP_036730.1 lipoprotein lipase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipoprotein lipase activity IDA
IDA: Inferred from direct assay
11788374 RGD
enables triglyceride binding IDA
IDA: Inferred from direct assay
12551943 RGD
Biological Process GO Annotation Evidence References Source
involved in lipid catabolic process IDA
IDA: Inferred from direct assay
12551943 RGD
involved in negative regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
25931001 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11016888 RGD
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
11788374 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12551943 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lipoprotein lipase

  • phospholipase A1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P2752 Lipoprotein lipase, Pseudomonas sp / Phase 3
HY-117549 Ibrolipim Activator 99.48% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4153 Enlicitide chloride Inhibitor 99.11% Unkown
HY-N5015 Rosmanol Inhibitor 98.95% Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-116538 (10E,12Z)-Octadeca-10,12-dienoic acid Activator 99.10% Unkown
HY-101395A W146 TFA 98.22% Unkown
HY-128671 6-​Thioinosine 99.31% Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-119601 GRI918013 Inhibitor / Unkown
HY-RS07563 LCP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07772 LPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17184 Lpl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23635 Lpl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpl NCBI NCBI:4023