2. Gene
  3. NOS2 - nitric oxide synthase 2 Gene

NOS2 - nitric oxide synthase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as iNos; Nos2a

Gene ID: 24599 | Gene type: protein coding

About NOS2

Primary_assembly 10: 63,815,308-63,851,210 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 152 phenotypes. Biased expression in Adrenal (RPKM 16.6), Heart (RPKM 1.1) and 5 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and Enzyme binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; cellular response to cytokine stimulus; and response to bacterium. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

NOS2 Products(1)

mRNA Protein Name
NM_012611.3 NP_036743.3 nitric oxide synthase, inducible

NOS2 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (80 - 492)

Flavodoxin_1

Flavodoxin_1: pfam00258 (537 - 668)

FNR_like

FNR_like: cl06868 (732 - 1128)

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  • 1147 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, inducible

NOS type II

inducible NO synthase

inducible NOS

inducible nitric oxide synthase

nitric oxide synthase 2, inducible, macrophage

nitric oxide synthase, inducible-like

peptidyl-cysteine S-nitrosylase NOS2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12124 BBS-4 Inhibitor 99.51% Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-RS09437 NOS2 Human Pre-designed siRNA Set A / Unkown
HY-RS09438 Nos2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09439 NOS2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NOS2 NCBI NCBI:4843