NOS2 - nitric oxide synthase 2 Gene

Also Known as iNos; Nos2a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24599

About NOS2

Primary_assembly 10: 63,815,308-63,851,210 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 152 phenotypes. Biased expression in Adrenal (RPKM 16.6), Heart (RPKM 1.1) and 5 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; cellular response to cytokine stimulus; and response to bacterium. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

NOS2 Products (1)

mRNA Protein Name
NM_012611.3 NP_036743.3 nitric oxide synthase, inducible

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
15475520 RGD
enables actin binding IDA
IDA: Inferred from direct assay
15858215 RGD
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
15858215 RGD
enables cAMP-dependent protein kinase regulator activity IDA
IDA: Inferred from direct assay
12107056 RGD
enables cadherin binding IPI
IPI: Inferred from physical interaction
15858215 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16172396 RGD
enables nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
11788371 RGD
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
15858215 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21464294 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17293490 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IDA
IDA: Inferred from direct assay
12107056 RGD
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
15800493 RGD
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
12107056 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
22001142 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21975807 RGD
involved in cellular response to lithium ion IEP
IEP: Inferred from expression pattern
21994254 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cellular response to redox state IEP
IEP: Inferred from expression pattern
21964032 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21965676 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
18534083 RGD
involved in defense response to Gram-negative bacterium IEP
IEP: Inferred from expression pattern
16865779 RGD
involved in endothelial cell proliferation IEP
IEP: Inferred from expression pattern
15800493 RGD
involved in glycoside metabolic process IEP
IEP: Inferred from expression pattern
22006678 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
15001568 RGD
involved in nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
12826065 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12208351 RGD
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
12959638 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
12009427 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
21986892 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17919391 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
10997722 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
9001735 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
21107779 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
21986672 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9686345 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19329460 RGD
involved in response to oxygen-glucose deprivation IEP
IEP: Inferred from expression pattern
10997722 RGD
involved in response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
19802525 RGD
involved in retinoic acid receptor signaling pathway IEP
IEP: Inferred from expression pattern
15602748 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11943139 RGD
located in cytosol IDA
IDA: Inferred from direct assay
12085352 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
22019508 RGD
located in nucleus IDA
IDA: Inferred from direct assay
11943139 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17293490 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
12085352 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOS2 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (80 - 492)

Flavodoxin_1

Flavodoxin_1: pfam00258 (537 - 668)

FNR_like

FNR_like: cl06868 (732 - 1128)

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  • 1147 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, inducible

  • NOS type II

  • inducible NO synthase

  • inducible NOS

  • inducible nitric oxide synthase

  • nitric oxide synthase 2, inducible, macrophage

  • nitric oxide synthase, inducible-like

  • peptidyl-cysteine S-nitrosylase NOS2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0464 Hydralazine hydrochloride Inhibitor 99.97% Yes
HY-B0464A Hydralazine Inhibitor 99.94% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123823 Nitroaspirin 98.57% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N12586 Pheophytin a 80.0% Unkown
HY-12124 BBS-4 Inhibitor 99.49% Unkown
HY-B0464S1 Hydralazine-d5 hydrochloride Inhibitor 99.9% Unkown
HY-RS09438 Nos2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0464S Hydralazine-d4 hydrochloride Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-179407 LT-104A Inhibitor / Unkown
HY-RS09022 NANOS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09437 NOS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09439 NOS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11828 Rela Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NOS2 NCBI NCBI:4843