Spn - sialophorin Gene

Also Known as Lsn; Cd43; Lsn1; gpL115

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24796

Summary

Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]

Spn Products (1)

mRNA Protein Name
NM_001271086.1 NP_001258015.1 leukosialin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9472040 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
18614175 RGD
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
10486239 RGD
involved in monocyte activation IEP
IEP: Inferred from expression pattern
9400815 RGD
involved in regulation of gene expression IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in thymocyte aggregation IMP
IMP: Inferred from mutant phenotype
1382990 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
7758131 RGD
located in cleavage furrow IDA
IDA: Inferred from direct assay
8421057 RGD
located in microvillus IDA
IDA: Inferred from direct assay
8421057 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukosialin

  • W3/13 antigen

  • leukocyte sialoglycoprotein

  • leukosianin

Recombinant Spn Proteins

Cat. No. Product Name Accession Purity
HY-P75403 CD43 Protein, Rat (HEK293, Fc) R9PXZ7/NP_001258015.1 (Q21-S243) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107434 Molindone Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149004 SLF1081851 Inhibitor 98.02% Unkown
HY-P0242A Neurokinin B TFA Agonist 99.36% Unkown
HY-162655 SLF80821178 Inhibitor 99.70% Unkown
HY-P0242 Neurokinin B Agonist 98.48% Unkown
HY-150254A SLB1122168 formic Inhibitor 99.91% Unkown
HY-150254 SLB1122168 Inhibitor / Unkown
HY-149004A SLF1081851 TFA Inhibitor / Unkown
HY-149004B SLF1081851 hydrochloride / Unkown
HY-156408 Spns2-IN-1 Inhibitor / Unkown
HY-162655A SLF80821178 hydrochloride Inhibitor / Unkown
HY-162996 Spns2-IN-2 Inhibitor / Unkown
HY-182375 (R)-SLB1122168 free base Inhibitor / Unkown
HY-182375A SLB1122168 free base Inhibitor / Unkown
HY-182456 CHDI-340246 Inhibitor / Unkown
HY-P10312 SPN009 Agonist / Unkown
HY-RS03666 DEAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11006 PPP1R9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13689 SPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13691 SPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13692 SPNS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107434S Molindone-d8 Inhibitor 99.49% Unkown
HY-RS18595 Spn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19483 Spns2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25080 Spn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25976 Spns2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spn NCBI NCBI:6693