Adrb1 - adrenoceptor beta 1 Gene

Also Known as B1AR; RATB1AR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24925

Summary

Enables amine binding activity and beta1-adrenergic receptor activity. Involved in several processes, including positive regulation of transport; regulation of heart contraction; and regulation of muscle system process. Located in cytoplasm; nucleus; and plasma membrane. Used to study congestive heart failure; dilated cardiomyopathy; myocardial infarction; periodontitis; and renovascular hypertension. Biomarker of hyperglycemia; hypertension; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Adrb1 Products (1)

mRNA Protein Name
NM_012701.2 NP_036833.2 beta-1 adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amine binding IPI
IPI: Inferred from physical interaction
6289140 RGD
enables beta1-adrenergic receptor activity IDA
IDA: Inferred from direct assay
12514203 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16316992 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12514203 RGD
involved in Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
18306009 RGD
involved in glycogen catabolic process IDA
IDA: Inferred from direct assay
17911346 RGD
involved in inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
18262504 RGD
involved in lipid homeostasis IMP
IMP: Inferred from mutant phenotype
22457517 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
17961922 RGD
involved in negative regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18306009 RGD
involved in negative regulation of urine volume IDA
IDA: Inferred from direct assay
7912752 RGD
involved in positive regulation of adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
21143600 RGD
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18202135 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17143192 RGD
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
11408541 RGD
involved in positive regulation of cation channel activity IDA
IDA: Inferred from direct assay
22505670 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
18194989 RGD
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
9089896 RGD
involved in positive regulation of long-term synaptic potentiation IDA
IDA: Inferred from direct assay
21848869 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
18931026 RGD
involved in positive regulation of the force of heart contraction by norepinephrine IDA
IDA: Inferred from direct assay
19133992 RGD
involved in protein localization to organelle IDA
IDA: Inferred from direct assay
22105697 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
19133992 RGD
involved in regulation of cardiac muscle cell contraction IDA
IDA: Inferred from direct assay
19525381 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
22216755 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12391161 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-1 adrenergic receptor

  • adrenergic receptor, beta 1

  • adrenergic, beta-1-, receptor

  • beta 1-adrenergic receptor beta 1-AR

  • beta-1 adrenoceptor

  • beta-1 adrenoreceptor

Adrb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Adrb1 P18090 Magi3 Rattus norvegicus Q9JK71
Anti Bait CoIP
16316992
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00414 ADRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18054 Adrb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24529 Adrb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adrb1 NCBI NCBI:153