2. Gene
  3. Acat1 - acetyl-CoA acetyltransferase 1 Gene

Acat1 - acetyl-CoA acetyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RATACAL

Gene ID: 25014 | Gene type: protein coding

About Acat1

Primary_assembly 8: 53,979,813-54,008,855 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 1952.7), Kidney (RPKM 13.6) and 9 other tissues.

Summary

Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; response to hormone; and response to starvation. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acat1 Products(1)

mRNA Protein Name
NM_017075.2 NP_058771.2 acetyl-CoA acetyltransferase, mitochondrial precursor

Acat1 Protein Structure

thiolase

thiolase: cd00751 (39 - 422)

  • 0
  • 100
  • 200
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  • 424 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, mitochondrial

acetoacetyl-CoA thiolase

acetyl-Co A acetyltransferase 1 mitochondrial

acetyl-coenzyme A acetyltransferase 1

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13215 Avasimibe Inhibitor 99.50% Phase 3
HY-100401A Pactimibe sulfate Inhibitor 98.22% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor ≥99.0% Phase 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Acat1 NCBI NCBI:38