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Fgfr2 - fibroblast growth factor receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25022

About Fgfr2

Primary_assembly 1: 184,745,420-184,850,626 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 221 orthologues, 54 paralogues and is associated with 75 phenotypes. Biased expression in Adrenal (RPKM 15.3), Lung (RPKM 131.4) and 9 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and fibroblast growth factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of smooth muscle cell proliferation. Located in cell surface; cytoplasm; and nucleus. Used to study prostate Cancer and retinitis pigmentosa. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; dysgerminoma; and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products (6)

mRNA	Protein	Name
NM_001109892.1	NP_001103362.1	fibroblast growth factor receptor 2 isoform b
NM_001109895.1	NP_001103365.1	fibroblast growth factor receptor 2 isoform e
NM_001109896.1	NP_001103366.1	fibroblast growth factor receptor 2 isoform f
NM_001109893.1	NP_001103363.1	fibroblast growth factor receptor 2 isoform c
NM_001109894.1	NP_001103364.1	fibroblast growth factor receptor 2 isoform d
NM_012712.1	NP_036844.1	fibroblast growth factor receptor 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	15282342	RGD
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	7803853	RGD
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	15282342	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	9373031	RGD
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	28981091	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	31093967	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	15389522	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	12648559	RGD
involved in endochondral bone growth	IEP IEP: Inferred from expression pattern	17169623	RGD
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	7803853	RGD
involved in fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15282342	RGD
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15292181	RGD
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	7803853	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	9537256	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15292181	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16770775	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19524256	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15614790	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr2 Protein Structure

IgI_2_FGFR

PTKc_FGFR2

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200
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841 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-165298	DGY-09-192	Degrader	99.50%	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-184322	LC-MG-10	Degrader	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown
HY-184321	LC-MG-5	Degrader	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991584	HuGAL-FR21	Inhibitor	97.80%	Unkown
HY-P991583	GP369	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr2	NCBI	NCBI:2263