Mapk10 - mitogen activated protein kinase 10 Gene

Also Known as Jnk3; SAPb; SAPKC; Serk2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25272

About Mapk10

Primary_assembly 14: 6,497,707-6,786,201 forward strand.mRatBN7.2:CM026987.1

This gene has 5 transcripts (splice variants), 223 orthologues, 21 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 116.3), Testes (RPKM 7.1) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Mapk10 Products (3)

mRNA	Protein	Name
NM_012806.2	NP_036938.2	mitogen-activated protein kinase 10 isoform 2
NM_001270556.1	NP_001257485.1	mitogen-activated protein kinase 10 isoform 1
NM_001318190.1	NP_001305119.1	mitogen-activated protein kinase 10 isoform 1x

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10051439	RGD
enables JUN kinase activity	IDA IDA: Inferred from direct assay	10051439	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18046461	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	10051439	RGD
involved in JUN phosphorylation	IDA IDA: Inferred from direct assay	10597270	RGD
involved in cellular hyperosmotic response	IEP IEP: Inferred from expression pattern	10950813	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21113145	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	EXP EXP: Inferred from Experiment	23838184	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IDA IDA: Inferred from direct assay	23838184	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	23838184	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10051439	RGD
involved in vesicle-mediated transport in synapse	EXP EXP: Inferred from Experiment	23838184	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	23838184	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	23838184	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23838184	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23838184	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23838184	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10950813	RGD
is active in postsynaptic Golgi apparatus	IDA IDA: Inferred from direct assay	23838184	RGD
is active in postsynaptic Golgi apparatus	IMP IMP: Inferred from mutant phenotype	23838184	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk10 Protein Structure

STKc_JNK

0
100
200
300
400
478 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 10	MAP kinase 10 MAPK 10 SAPK-beta Stress activated protein kinase beta c-Jun N-terminal kinase 3 p54-beta stress-activated protein kinase JNK3

Mapk10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mapk10	P49187	Syt4	Rattus norvegicus	P50232	Pull Down	18046461

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169067	10-Methoxy-canthin-6-one		98.71%	Unkown
HY-N20679	Aequinetin	Inhibitor	/	Unkown
HY-RS08095	MAPK10 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08096	Mapk10 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08097	Mapk10 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk10	NCBI	NCBI:5602