Cnp - 2',3'-cyclic nucleotide 3' phosphodiesterase Gene

Also Known as CNPF; CNPI; Cnp1; CNPII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25275

Summary

Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity and cyclic nucleotide binding activity. Involved in several processes, including aging; regulation of mitochondrial membrane permeability; and response to lipopolysaccharide. Located in several cellular components, including mitochondrial membrane; myelin sheath abaxonal region; and myelin sheath adaxonal region. Used to study carotid stenosis. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Apr 2022]

Cnp Products (1)

mRNA Protein Name
NM_012809.2 NP_036941.1 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
IDA: Inferred from direct assay
19357238 RGD
enables cyclic nucleotide binding IDA
IDA: Inferred from direct assay
19357238 RGD
Biological Process GO Annotation Evidence References Source
involved in forebrain development IEP
IEP: Inferred from expression pattern
16876328 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
19357238 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17000237 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
16051705 RGD
located in microvillus IDA
IDA: Inferred from direct assay
16876328 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19357238 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
19357238 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
16051705 RGD
located in myelin sheath adaxonal region IDA
IDA: Inferred from direct assay
16051705 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11842207 RGD
located in pseudopodium IDA
IDA: Inferred from direct assay
16876328 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2',3'-cyclic-nucleotide 3'-phosphodiesterase

  • CNPase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3503 Vosoritide Inhibitor 99.89% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-119689 Umibecestat Inhibitor 99.81% Phase 3
HY-P3624 Cenderitide Agonist 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1237 C-Type Natriuretic Peptide (CNP) (1-22), human Inhibitor 99.84% Unkown
HY-112411 PD 174265 98.35% Unkown
HY-P5127 CNP-38 99.87% Unkown
HY-P1237A C-Type Natriuretic Peptide (CNP) (1-22), human TFA 99.07% Unkown
HY-153102 G3-CNP 98.61% Unkown
HY-137672A 2',3'-Cyclic NADP disodium Activator 95% Unkown
HY-143316 NPR-C activator 1 Activator 99.30% Unkown
HY-P1556A Vasonatrin Peptide (VNP) TFA 98.79% Unkown
HY-15911 CNP-AFU 99.76% Unkown
HY-175340 Kv7.2/Kv7.3 activator-3 Activator / Unkown
HY-183967 CNP7 / Unkown
HY-P11861 CNP analogue-1 Activator / Unkown
HY-P1556 Vasonatrin Peptide (VNP) / Unkown
HY-RS02910 CNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09496 NPPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153101 Gal-G2-CNP / Unkown
HY-N12612 CNP0296775 Inhibitor / Unkown
HY-RS17182 Cnp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20311 Nppc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23633 Cnp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W330621 2-Chloro-4-nitrophenyl-α-D-glucopyranoside / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnp NCBI NCBI:1267