CNP - 2',3'-cyclic nucleotide 3' phosphodiesterase Gene

Also Known as CNP1; HLD20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1267

About CNP

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,966,795-41,977,740 (from NCBI)

This gene has 12 transcripts (splice variants), 196 orthologues and is associated with 1 phenotype. Broad expression in brain (RPKM 130.3), kidney (RPKM 16.0) and 18 other tissues.

Summary

Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome. [provided by Alliance of Genome Resources, Apr 2022]

CNP Products (2)

mRNA	Protein	Name
NM_001330216.2	NP_001317145.1	2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2
NM_033133.5	NP_149124.3	2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNP Protein Structure

AAA_33

CNPase

0
100
200
300
400
421 a.a.

Protein Preferred Names	Protein Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase	2', 3' cyclic nucleotide 3' phosphohydrolase

CNP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CNP	P09543	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CNP	P09543	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CNP	P09543	HTT	Homo sapiens	P42858	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CNP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80087	CNPase Antibody (YA496)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukodystrophy, Hypomyelinating, 20	HLD20 Hypomyelinating Leukodystrophy 20
Myopia 2, Autosomal Dominant	Myopia 2 MYP2 Myopia-2 Myopia, Autosomal Dominant, Type 2
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating
Leukodystrophy	Leukodystrophies
Cutaneous Ganglioneuroma	Ganglioneuroma Of Skin
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Allergic Urticaria
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Niemann-Pick Disease, Type A	Niemann-Pick Disease Type A Sphingomyelin Lipidosis Sphingomyelinase Deficiency Niemann-Pick Disease, Intermediate, Protracted Neurovisceral Acid Sphingomyelinase Deficiency, Neurovisceral Type Asmd, Neurovisceral Type Infantile Neurovisceral Acid Sphingomyelinase Deficiency Infantile Neurovisceral Asmd Npd-A Niemann-Pick Disease A NPDA Classical Niemann-Pick Disease Niemann-Pick Disease Acute Neuronopathic Form Niemann-Pick Disease Acute Neurovisceral Form Niemann-Pick Disease Classical Infantile Form Niemann-Pick Disease Intermediate Protracted Neurovisceral Niemann-Pick Disease Neuronopathic Type Niemann-Pick Disease Type I Npa Niemann-Pick Diseases
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Spastic Quadriplegia	Spastic Quadriplegic Cerebral Palsy Quadriplegic Infantile Cerebral Palsy Tetraplegic Infantile Cerebral Palsy Cerebral Palsy Spastic Quadriplegic Quadriplegic Cerebral Palsy Spastic Quadriplegia Cerebral Palsy Spastic Tetraplegia Cerebral Palsy Cerebral Palsy, Quadriplegic, Infantile Cerebral Palsy With Spastic Tetraplegia Congenital Spastic Quadriplegia Spastic Tetraplegic Cerebral Palsy Congenital Quadriplegia Nos Tetraplegic Cerebral Palsy
Pelizaeus-Merzbacher Disease	PMD HLD1 Pelizaeus-Merzbacher Brain Sclerosis Leukodystrophy, Hypomyelinating, 1 Diffuse Familial Brain Sclerosis Pelizaeus Merzbacher Brain Sclerosis Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type Cockayne-Pelizaeus-Merzbacher Disease Hypomyelinating Leukodystrophy 1 Leukodystrophy, Sudanophilic Pelizaeus Merzbacher Disease Hypomyelinating Leukodystrophy, 1 Sudanophilic Leukodystrophy Pelizaeus-Merzbacher Disease, Connatal Form Connatal Pmd Pelizaeus-Merzbacher Disease Type Ii Severe Pmd Null Syndrome Plp1 Null Syndrome Pelizaeus-Merzbacher Disease, Null Syndrome Brain Sclerosis Diffuse Familial Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type Leukodystrophy Hypomyelinating 1 Diffuse Cerebral Sclerosis Of Schilder
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Striatonigral Degeneration
Alcoholic Liver Cirrhosis	Alcoholic Cirrhosis Portal Cirrhosis Alcoholic Cirrhosis Of Liver Liver Cirrhosis, Alcoholic Laennec'S Cirrhosis Laennec'S Cirrhosis, Alcoholic Alcohol Cirrhosis Alcoholic Laennec Cirrhosis Alcoholic Cirrhosis Nos Etoh Cirrhosis Alcohol Hepatic Cirrhosis Alcohol Liver Cirrhosis Laennec Cirrhosis
Quadriplegia	Tetraplegia Tetraplegias
Olivopontocerebellar Atrophy	Thomas Syndrome Olivopontocerebellar Atrophies Dejerine-Thomas Syndrome Thomas' Syndrome Wadia-Swami Syndrome Opca Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome Spinocerebellar Ataxia Type 2
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Mannosidosis, Beta A, Lysosomal	Beta-Mannosidosis Lysosomal Beta-Mannosidase Deficiency Beta-Mannosidase Deficiency Beta-D-Mannosidosis Mannosidosis, Beta MANSB Lysosomal Beta A Mannosidosis
Spastic Paraplegia 2, X-Linked	SPG2 Hereditary Spastic Paraplegia 2 Sppx2 Spastic Paraplegia Type 2 Spastic Paraplegia 2 Hereditary X-Linked Recessive Spastic Paraplegia X-Linked Spastic Paraplegia 2 X Linked Recessive Hereditary Spastic Paraplegia Spastic Gait Type 2 Spastic Paraparesis Type 2 X-Linked Spastic Paraplegia Type 2 Spastic Paraplegia Type 2, X-Linked Spastic Paraplegia-2 Paraplegia, Spastic, Type 2
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Hypertrophic Neuropathy Of Dejerine-Sottas	Dejerine-Sottas Disease Dejerine-Sottas Syndrome Charcot-Marie-Tooth Disease Type 3 DSS Hereditary Motor And Sensory Neuropathy Type Iii Hmsn3 Dejerine-Sottas Neuropathy Hmsn Iii Charcot-Marie-Tooth Disease, Type 3 Cmt3 Dsn Hmsn 3 Hereditary Motor And Sensory Neuropathy Type 3 Hereditary Motor And Sensory Neuropathy 3 Hypertrophic Neuropathy Of Infancy Charcot-Marie-Tooth Disease Demyelinating Type 4f Charcot-Marie-Tooth Disease Type 4f Charcot-Marie-Tooth Neuropathy Type 4f Cmt4f Hereditary Motor And Sensory Neuropathy Iii Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3503	Vosoritide	Inhibitor	99.89%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-119689	Umibecestat	Inhibitor	99.81%	Phase 3
HY-P3624	Cenderitide	Agonist	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1237	C-Type Natriuretic Peptide (CNP) (1-22), human	Inhibitor	99.84%	Unkown
HY-112411	PD 174265		98.35%	Unkown
HY-P5127	CNP-38		99.87%	Unkown
HY-P1237A	C-Type Natriuretic Peptide (CNP) (1-22), human TFA		99.07%	Unkown
HY-153102	G3-CNP		98.61%	Unkown
HY-137672A	2',3'-Cyclic NADP disodium	Activator	95%	Unkown
HY-143316	NPR-C activator 1	Activator	99.30%	Unkown
HY-P1556A	Vasonatrin Peptide (VNP) TFA		98.79%	Unkown
HY-15911	CNP-AFU		99.76%	Unkown
HY-175340	Kv7.2/Kv7.3 activator-3	Activator	/	Unkown
HY-183967	CNP7		/	Unkown
HY-P11861	CNP analogue-1	Activator	/	Unkown
HY-P1556	Vasonatrin Peptide (VNP)		/	Unkown
HY-RS02910	CNP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09496	NPPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153101	Gal-G2-CNP		/	Unkown
HY-N12612	CNP0296775	Inhibitor	/	Unkown
HY-RS17182	Cnp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20311	Nppc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23633	Cnp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W330621	2-Chloro-4-nitrophenyl-α-D-glucopyranoside		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CNP	MGD	MGI:88437
Macaca mulatta	CNP	VGNC	VGNC:71279
Canis familiaris	CNP	VGNC	VGNC:39421
Rattus norvegicus	CNP	RGD	RGD:2368
Felis catus	CNP	VGNC	VGNC:61031
Bos taurus	CNP	VGNC	VGNC:27525
Others	CNP	NCBI