RNF169 - ring finger protein 169 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254225

About RNF169

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,748,849-74,842,413 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 6.7), bone marrow (RPKM 6.4) and 25 other tissues.

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity and nucleosome binding activity. Involved in cellular response to DNA damage stimulus and negative regulation of double-strand break repair. Located in cytosol; nuclear lumen; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

RNF169 Products (1)

mRNA Protein Name
NM_001098638.2 NP_001092108.1 E3 ubiquitin-protein ligase RNF169

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
22492721 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
22742833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin-modified histone reader activity IDA
IDA: Inferred from direct assay
22492721 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
22733822 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
22492721 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
22492721 GOA
involved in negative regulation of double-strand break repair IDA
IDA: Inferred from direct assay
22742833 GOA
involved in negative regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
22492721 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
22492721 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22733822 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
22492721 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF169 Protein Structure

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (66 - 108)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF169

  • RING-type E3 ubiquitin transferase RNF169

RNF169 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF169 Q8NCN4 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
RNF169 Q8NCN4 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
Intra
RNF169 Q8NCN4 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
RNF169 Q8NCN4 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
RNF169 Q8NCN4 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
RNF169 Q8NCN4 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RNF169 Q8NCN4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RNF169 Q8NCN4 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
RNF169 Q8NCN4 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
RNF169 Q8NCN4 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
RNF169 Q8NCN4 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
RNF169 Q8NCN4 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mixed Fibrolamellar Hepatocellular Carcinoma
Intellectual Developmental Disorder, Autosomal Dominant 7

  • MRD7

  • Mental Retardation, Autosomal Dominant 7

  • Autosomal Dominant Non-Syndromic Intellectual Disability 7

  • Dyrk1a Syndrome

  • Autosomal Dominant Intellectual Developmental Disorder 7

  • Autosomal Dominant Mental Retardation 7

  • Mental Retardation, Autosomal Dominant, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12063 RNF169 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21921 Rnf169 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28437 Rnf169 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF169 VGNC VGNC:34034
Felis catus RNF169 VGNC VGNC:104325
Canis familiaris RNF169 VGNC VGNC:45644
Macaca mulatta RNF169 VGNC VGNC:107634
Mus musculus RNF169 MGD MGI:1920257
Rattus norvegicus RNF169 RGD RGD:1583288
Others RNF169 NCBI