2. Gene
  3. Drd4 - dopamine receptor D4 Gene

Drd4 - dopamine receptor D4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as D4RA

Gene ID: 25432 | Gene type: protein coding

About Drd4

Primary_assembly 1: 196,396,366-196,399,553 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 247 orthologues, 35 paralogues and is associated with 28 phenotypes. Biased expression in Heart (RPKM 5.8), Thymus (RPKM .8) and 3 other tissues.

Summary

Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (Dopamine Receptor D4). [provided by Alliance of Genome Resources, Apr 2022]

Drd4 Products(1)

mRNA Protein Name
NM_012944.2 NP_037076.2 D(4) dopamine receptor

Drd4 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (43 - 380)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 90)

7tm_GPCRs

7tm_GPCRs: cd14964 (107 - 129)

7tm_GPCRs

7tm_GPCRs: cd14964 (150 - 166)

7tm_GPCRs

7tm_GPCRs: cd14964 (186 - 209)

7tm_GPCRs

7tm_GPCRs: cd14964 (314 - 336)

7tm_GPCRs

7tm_GPCRs: cd14964 (348 - 373)

  • 0
  • 100
  • 200
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  • 389 a.a.
Protein Preferred Names Protein Names

D(4) dopamine receptor

d(2C) dopamine receptor

dopamine D4 receptor

dopamine receptor 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125751 UCSF924 Agonist 99.56% Unkown
HY-103407 PD 168568 Antagonist / Unkown
HY-103407A PD 168568 dihydrochloride Antagonist / Unkown
HY-147398 Dopamine D4 receptor antagonist-1 Antagonist / Unkown
HY-RS04003 DRD4 Human Pre-designed siRNA Set A / Unkown
HY-RS04004 Drd4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04005 Drd4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd4 NCBI NCBI:1815