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Drd4 - dopamine receptor D4 Gene

Also Known as D4RA

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25432

About Drd4

Primary_assembly 1: 196,396,366-196,399,553 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 247 orthologues, 35 paralogues and is associated with 28 phenotypes. Biased expression in Heart (RPKM 5.8), Thymus (RPKM .8) and 3 other tissues.

Summary

Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (Dopamine Receptor D4). [provided by Alliance of Genome Resources, Apr 2022]

Drd4 Products (1)

mRNA	Protein	Name
NM_012944.2	NP_037076.2	D(4) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dopamine binding	IDA IDA: Inferred from direct assay	15448188	RGD
enables dopamine binding	IPI IPI: Inferred from physical interaction	8078498	RGD
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IDA: Inferred from direct assay	12711714	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	8078498	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	8078498	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14499480	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	12711714	RGD
involved in associative learning	IMP IMP: Inferred from mutant phenotype	15987936	RGD
involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	16708027	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	18778704	RGD
involved in modulation of inhibitory postsynaptic potential	IDA IDA: Inferred from direct assay	12417643	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	17314300	RGD
involved in negative regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12417643	RGD
involved in negative regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	24888351	RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	24888351	RGD
involved in olfactory learning	IMP IMP: Inferred from mutant phenotype	15987936	RGD
involved in photoperiodism	IEP IEP: Inferred from expression pattern	18321474	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21622557	RGD
involved in positive regulation of penile erection	IDA IDA: Inferred from direct assay	15814200	RGD
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	9497025	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	24155292	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24155292	RGD
involved in regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	15229297	RGD
involved in regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	15363981	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	14586014	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	14586014	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	14586014	RGD
involved in regulation of protein kinase A signaling	IDA IDA: Inferred from direct assay	12417643	RGD
involved in response to epinephrine	IEP IEP: Inferred from expression pattern	19482058	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23413777	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	19482058	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	18809391	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	19482058	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	18778704	RGD
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	15138447	RGD
involved in synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	15476261	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	24155292	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	24155292	RGD
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11902112	RGD
located in axon	IDA IDA: Inferred from direct assay	10819901	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	14519509	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	10898094	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11902112	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	11902112	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10819901	RGD
located in dendrite terminus	IDA IDA: Inferred from direct assay	11902112	RGD
located in dendritic microtubule	IDA IDA: Inferred from direct assay	11902112	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	11902112	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	10819901	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11902112	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	14586014	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14586014	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	11902112	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10898094	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	11902112	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12133912	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14519509	RGD
located in presynapse	IDA IDA: Inferred from direct assay	11902112	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14519509	RGD
located in synapse	IDA IDA: Inferred from direct assay	11902112	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	10819901	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd4 Protein Structure

7tm_GPCRs

0
100
200
300
389 a.a.

Protein Preferred Names	Protein Names
D(4) dopamine receptor	d(2C) dopamine receptor dopamine D4 receptor dopamine receptor 4

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107121	Ondelopran	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125751	UCSF924	Agonist	99.53%	Unkown
HY-147398	Dopamine D4 receptor antagonist-1	Antagonist	98.59%	Unkown
HY-103407A	PD 168568 dihydrochloride	Antagonist	99.71%	Unkown
HY-RS04004	Drd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103407	PD 168568	Antagonist	/	Unkown
HY-RS04003	DRD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04005	Drd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd4	NCBI	NCBI:1815