CALHM1 - calcium homeostasis modulator 1 Gene

Also Known as FAM26C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 255022

About CALHM1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,453,240-103,458,900 (from NCBI)

This gene has 1 transcript (splice variant), 217 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a Calcium Channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]

CALHM1 Products (1)

mRNA Protein Name
NM_001001412.4 NP_001001412.3 calcium homeostasis modulator protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-activated cation channel activity IDA
IDA: Inferred from direct assay
22711817 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18585350 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables voltage-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
22711817 GOA
Biological Process GO Annotation Evidence References Source
involved in ATP export IDA
IDA: Inferred from direct assay
32832629 GOA
involved in monoatomic cation transport IDA
IDA: Inferred from direct assay
22711817 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
23300080 GOA
involved in regulation of monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
23300080 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22711817 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALHM1 Protein Structure

Ca_hom_mod

Ca_hom_mod: Calcium homeostasis modulator (2 - 256)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

calcium homeostasis modulator protein 1

  • family with sequence similarity 26, member C

CALHM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CALHM1 Q8IU99 CALHM1 Homo sapiens Q8IU99
Anti Tag CoIP
18585350
Intra
CALHM1 Q8IU99 CSNK1D Homo sapiens P48730-2
Validated Y2H
32814053
Intra
CALHM1 Q8IU99 CSNK1D Homo sapiens P48730-2
Y2H Pooling
32814053
Intra
CALHM1 Q8IU99 CSNK1D Homo sapiens P48730-2
Y2H Array
32814053
Intra
CALHM1 Q8IU99 CALHM1 Homo sapiens Q8IU99
Comig Non-Denat Gel
18585350
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer'S Disease 1

  • Alzheimer Disease Type 1

  • Alzheimer'S Disease 1, Early Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117073 ITH12575 Inhibitor 98.84% Unkown
HY-RS01837 CALHM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19765 Calhm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26262 Calhm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CALHM1 VGNC VGNC:26707
Felis catus CALHM1 VGNC VGNC:60323
Macaca mulatta CALHM1 VGNC VGNC:70615
Mus musculus CALHM1 MGD MGI:3643383
Canis familiaris CALHM1 VGNC VGNC:38667
Rattus norvegicus CALHM1 RGD RGD:1564891
Others CALHM1 NCBI