TPGS2 - tubulin polyglutamylase complex subunit 2 Gene

Also Known as L17; PGs2; C18orf10; HMFN0601

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25941

About TPGS2

This gene has 21 transcripts (splice variants) and 227 orthologues. Broad expression in testis (RPKM 16.4), brain (RPKM 5.6) and 24 other tissues.

Summary

This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

TPGS2 Products (10)

mRNA Protein Name
NM_001271949.2 NP_001258878.1 tubulin polyglutamylase complex subunit 2 isoform 2
NM_001271950.2 NP_001258879.1 tubulin polyglutamylase complex subunit 2 isoform 3
NM_001271951.2 NP_001258880.1 tubulin polyglutamylase complex subunit 2 isoform 4
NM_001271952.2 NP_001258881.1 tubulin polyglutamylase complex subunit 2 isoform 5
NM_001271953.2 NP_001258882.1 tubulin polyglutamylase complex subunit 2 isoform 6
NM_001271954.2 NP_001258883.1 tubulin polyglutamylase complex subunit 2 isoform 7
NM_001271955.2 NP_001258884.1 tubulin polyglutamylase complex subunit 2 isoform 8
NM_001271956.2 NP_001258885.1 tubulin polyglutamylase complex subunit 2 isoform 9
NM_001330572.2 NP_001317501.1 tubulin polyglutamylase complex subunit 2 isoform 10
NM_015476.4 NP_056291.2 tubulin polyglutamylase complex subunit 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin polyglutamylase complex subunit 2

  • polyglutamylase subunit 2

TPGS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPGS2 Q68CL5 OTP Homo sapiens Q5XKR4
Y2H Prey Pooling
32296183
Intra
TPGS2 Q68CL5 OTP Homo sapiens Q5XKR4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotrichosis 2

  • HYPT2

  • Hypotrichosis Simplex Of The Scalp 1

  • Htss1

  • Htss

  • Hypotrichosis, Spanish Type

  • Spanish Type Hypotrichosis

  • Hypotrichosis Spanish Type

  • Hypotrichosis, Type 2

  • Hypotrichosis Simplex Of Scalp
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14931 TPGS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TPGS2 VGNC VGNC:36248
Mus musculus TPGS2 MGD MGI:1913898
Canis familiaris TPGS2 VGNC VGNC:47737
Rattus norvegicus TPGS2 RGD RGD:1310571
Macaca mulatta TPGS2 VGNC VGNC:79442
Others TPGS2 NCBI