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LRP10 - LDL receptor related protein 10 Gene

Also Known as LRP9; LRP-10; MST087; MSTP087

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26020

About LRP10

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,871,740-22,881,713 (from NCBI)

This gene has 5 transcripts (splice variants), 177 orthologues and 14 paralogues. Ubiquitous expression in esophagus (RPKM 34.1), colon (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of Apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

LRP10 Products (2)

mRNA	Protein	Name
NM_001329226.2	NP_001316155.1	low-density lipoprotein receptor-related protein 10 isoform 2 precursor
NM_014045.5	NP_054764.2	low-density lipoprotein receptor-related protein 10 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP10 Protein Structure

Ldl_recept_a

CUB

Ldl_recept_a

0
200
400
600
713 a.a.

Protein Preferred Names	Protein Names
low-density lipoprotein receptor-related protein 10

LRP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRP10	Q7Z4F1	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	FIMP	Homo sapiens	Q96LL3	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	FIMP	Homo sapiens	Q96LL3	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	FIMP	Homo sapiens	Q96LL3	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	PDCD1LG2	Homo sapiens	Q9BQ51	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	ST6GALNAC6	Homo sapiens	Q969X2	Validated Y2H	32296183
Intra	LRP10	Q7Z4F1	ST6GALNAC6	Homo sapiens	Q969X2	Y2H Prey Pooling	32296183
Intra	LRP10	Q7Z4F1	ST6GALNAC6	Homo sapiens	Q969X2	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183
Intra	LRP10	Q7Z4F1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRP10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76475	LRP-10 Protein, Human (HEK293, Fc)	Q7Z4F1-1 (H17-K440)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P76476	LRP-10 Protein, Human (HEK293, His)	Q7Z4F1-1 (H17-K440)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies	Murcs Association Mayer-Rokitansky-Kuster-Hauser Syndrome Type 2 Mrkh Syndrome Type 2 Mayer-Rokitansky-Küster-Hauser Syndrome Type 2 MURCS Klippel-Feil Deformity, Conductive Deafness, And Absent Vagina Atypical Mrkh Syndrome Mullerian Duct Aplasia-Renal Dysplasia-Cervical Somite Anomalies Syndrome Mayer-Rokitansky-Kuster-Hauser Syndrome, Type Ii Mrkh, Type Ii Mullerian Duct Aplasia, Unilateral Renal Aplasia, And Cervicothoracic Somite Dysplasia Klippel-Feil Deformity - Conductive Deafness - Absent Vagina Müllerian Aplasia - Renal Aplasia - Cervicothoracic Somite Dysplasia
Retinitis Pigmentosa 37	RP37 Retinitis Pigmentosa-37 Retinitis Pigmentosa, Type 37
Ovarian Embryonal Carcinoma	Embryonal Carcinoma Of Ovary Embryonal Carcinoma Of The Ovary
Angiostrongyliasis	A. Cantonensis Angiostrongyliasis
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07793	LRP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07799	LRP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21634	Lrp10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28152	Lrp10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LRP10	MGD	MGI:1929480
Felis catus	LRP10	VGNC	VGNC:63284
Bos taurus	LRP10	VGNC	VGNC:30987
Rattus norvegicus	LRP10	RGD	RGD:1310471
Canis familiaris	LRP10	VGNC	VGNC:42772
Macaca mulatta	LRP10	VGNC	VGNC:74290
Others	LRP10	NCBI