EDRF1 - erythroid differentiation regulatory factor 1 Gene

Also Known as C10orf137

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26098

Summary

This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Broad expression in testis (RPKM 13.3), lymph node (RPKM 7.1) and 25 other tissues.

EDRF1 Products (2)

mRNA Protein Name
NM_001202438.2 NP_001189367.1 erythroid differentiation-related factor 1 isoform 1
NM_015608.3 NP_056423.2 erythroid differentiation-related factor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12609092 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDRF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EDRF1 Q3B7T1 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
EDRF1 Q3B7T1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
EDRF1 Q3B7T1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
EDRF1 Q3B7T1 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra
EDRF1 Q3B7T1 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra
EDRF1 Q3B7T1 PHYH Homo sapiens O14832
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y0337A L-Cysteine hydrochloride 98.0% Yes