LRRC32 - leucine rich repeat containing 32 Gene

Also Known as GARP; CPPRDD; D11S833E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2615

About LRRC32

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,657,524-76,670,747 (from NCBI)

This gene has 5 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 24.7), lung (RPKM 19.4) and 23 other tissues.

Summary

This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

LRRC32 Products (7)

mRNA Protein Name
NM_001128922.2 NP_001122394.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370187.1 NP_001357116.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370188.1 NP_001357117.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370189.1 NP_001357118.1 transforming growth factor beta activator LRRC32 isoform b
NM_001370190.1 NP_001357119.1 transforming growth factor beta activator LRRC32 isoform c
NM_001370191.1 NP_001357120.1 transforming growth factor beta activator LRRC32 isoform d precursor
NM_005512.3 NP_005503.1 transforming growth factor beta activator LRRC32 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19651619 GOA
enables receptor ligand inhibitor activity IDA
IDA: Inferred from direct assay
22278742 GOA
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
22278742 GOA
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
19651619 GOA
Biological Process GO Annotation Evidence References Source
involved in establishment of protein localization to extracellular region IDA
IDA: Inferred from direct assay
19750484 GOA
involved in establishment of protein localization to extracellular region IMP
IMP: Inferred from mutant phenotype
19651619 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
19750484 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19651619 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC32 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (22 - 48)

LRR_8

LRR_8: Leucine rich repeat (52 - 109)

LRR_8

LRR_8: Leucine rich repeat (149 - 209)

(219 - 231)

LRR_1

LRR_1: Leucine Rich Repeat (317 - 338)

LRR_8

LRR_8: Leucine rich repeat (365 - 421)

LRR_8

LRR_8: Leucine rich repeat (516 - 573)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta activator LRRC32

  • garpin

LRRC32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRC32 Q14392 TGFB1 Homo sapiens P01137
Anti Tag CoIP
33961781
Intra
LRRC32 Q14392 TGFB1 Homo sapiens P01137
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRC32 Proteins

Cat. No. Product Name Accession Purity
HY-P70419 LRRC32 Protein, Human (HEK293, Fc) Q14392 (H20-N627) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72636 GARP&Latent TGF beta 1 Complex Protein, Human (HEK293, His, Strep) P01137&Q14392 (L30-S390&H20-N627) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77671 GARP (Y137H)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, Y137H)&P01137 (L30-S390) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77672 GARP (S138G)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, S138G)&P01137 (L30-S390) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77673 GARP (G139N)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, G139N)&P01137 (L30-S390) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77674 GARP&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628)&P01137 (L30-S390) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77675 GARP&Latent TGF beta Complex Protein, Human (Biotinylated, HEK293, His-Avi) Q14392 (H20-L628,GARP)&P01137 (L30-S390,Latent TGF bata 1) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77676 GARP (Mutated)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, Y137H, S138G, G139N)&P01137 (L30-S390) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Cleft Palate, Proliferative Retinopathy, And Developmental Delay

  • CPPRDD
Vitreoretinal Degeneration
Vitreoretinopathy
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07815 LRRC32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17928 Lrrc32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24398 Lrrc32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRRC32 VGNC VGNC:63294
Macaca mulatta LRRC32 VGNC VGNC:101300
Canis familiaris LRRC32 VGNC VGNC:59054
Bos taurus LRRC32 VGNC VGNC:54884
Rattus norvegicus LRRC32 RGD RGD:1309087
Mus musculus LRRC32 MGD MGI:93882
Others LRRC32 NCBI