LRRC32 - leucine rich repeat containing 32 Gene

Homo sapiens

Also known as GARP; CPPRDD; D11S833E

Gene ID: 2615 | Gene type: protein coding

About LRRC32

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,657,524-76,670,747 (from NCBI)

This gene has 5 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 24.7), lung (RPKM 19.4) and 23 other tissues.

Summary

This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

LRRC32 Products(7)

mRNA	Protein	Name
NM_001128922.2	NP_001122394.1	transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370187.1	NP_001357116.1	transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370188.1	NP_001357117.1	transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370189.1	NP_001357118.1	transforming growth factor beta activator LRRC32 isoform b
NM_001370190.1	NP_001357119.1	transforming growth factor beta activator LRRC32 isoform c
NM_001370191.1	NP_001357120.1	transforming growth factor beta activator LRRC32 isoform d precursor
NM_005512.3	NP_005503.1	transforming growth factor beta activator LRRC32 isoform a precursor

LRRC32 Protein Structure

LRRNT

LRR_8

LRR_1

LRR_8

0
200
400
600
662 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta activator LRRC32

garpin

Recombinant LRRC32 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70419	LRRC32 Protein, Human (HEK293, Fc)	Q14392 (H20-N627)	≥95%
HY-P72636	GARP&Latent TGF Beta-1 Complex Protein, Human (HEK293, His, Strep)	P01137&Q14392 (L30-S390&H20-N627)	≥95%
HY-P77671	GARP (Y137H)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi)	Q14392 (H20-L628, Y137H)&P01137 (L30-S390)	≥95%
HY-P77672	GARP (S138G)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi)	Q14392 (H20-L628, S138G)&P01137 (L30-S390)	≥95%
HY-P77673	GARP (G139N)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi)	Q14392 (H20-L628, G139N)&P01137 (L30-S390)	≥95%
HY-P77674	GARP&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi)	Q14392 (H20-L628)&P01137 (L30-S390)	≥95%
HY-P77675	GARP&Latent TGF beta Complex Protein, Human (Biotinylated, HEK293, His-Avi)	Q14392 (H20-L628,GARP)&P01137 (L30-S390,Latent TGF bata 1)	≥95%
HY-P77676	GARP (Mutated)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi)	Q14392 (H20-L628, Y137H, S138G, G139N)&P01137 (L30	≥95%

Related Diseases

Diseases

Alias

Cleft Palate, Proliferative Retinopathy, And Developmental Delay

CPPRDD

Vitreoretinal Degeneration

Vitreoretinopathy

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99708	Livmoniplimab	Inhibitor	99.25%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07815	LRRC32 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRC32	VGNC	VGNC:63294
Macaca mulatta	LRRC32	VGNC	VGNC:101300
Canis familiaris	LRRC32	VGNC	VGNC:59054
Bos taurus	LRRC32	VGNC	VGNC:54884
Rattus norvegicus	LRRC32	RGD	RGD:1309087
Mus musculus	LRRC32	MGD	MGI:93882
Macaca fascicularis	LRRC32	NCBI
Others	LRRC32	NCBI

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