Afdn - afadin, adherens junction formation factor Gene

Also Known as Af6; Mllt4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 26955

Summary

Enables LIM domain binding activity. Involved in dendrite arborization; positive regulation of mini excitatory postsynaptic potential; and regulation of cell morphogenesis. Located in adherens junction; axon; and somatodendritic compartment. Colocalizes with excitatory synapse. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]

Afdn Products (1)

mRNA Protein Name
NM_013217.3 NP_037349.1 afadin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables LIM domain binding IPI
IPI: Inferred from physical interaction
15140894 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10974003 RGD
Biological Process GO Annotation Evidence References Source
involved in dendrite arborization IMP
IMP: Inferred from mutant phenotype
22948147 RGD
involved in positive regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
22948147 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
22948147 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
22948147 RGD
involved in positive regulation of mini excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
22948147 RGD
involved in postsynaptic specialization organization IDA
IDA: Inferred from direct assay
36803960 RGD
involved in postsynaptic specialization organization IMP
IMP: Inferred from mutant phenotype
36803960 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
9334353 RGD
located in axon IDA
IDA: Inferred from direct assay
18181141 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
22948147 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
36803960 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
36803960 RGD
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18181141 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

afadin

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

  • translocated to, 4

  • myeloid/lymp

Afdn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Afdn O35889 DBN1 Homo sapiens Q16643
Pull Down
23750010
Cross
Afdn O35889 DBN1 Homo sapiens Q16643
Anti Tag CoIP
23750010
Cross
Afdn O35889 DBN1 Homo sapiens Q16643
FRAP
23750010
Cross
Afdn O35889 Ctnna1 Mus musculus P26231
Pull Down
10974003
Cross
Afdn O35889 Ctnna1 Mus musculus P26231
Y2H
10974003
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00427 AFDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afdn NCBI NCBI:4301