CRCP - CGRP receptor component Gene

Also Known as C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27297

About CRCP

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:66,114,818-66,154,568 (from NCBI)

This gene has 7 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CRCP Products (5)

mRNA Protein Name
NM_001040648.2 NP_001035738.1 DNA-directed RNA polymerase III subunit RPC9 isoform c
NR_024548.2
NM_001040647.2 NP_001035737.1 DNA-directed RNA polymerase III subunit RPC9 isoform b
NM_014478.5 NP_055293.1 DNA-directed RNA polymerase III subunit RPC9 isoform a
NM_001142414.1 NP_001135886.1 DNA-directed RNA polymerase III subunit RPC9 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-directed 5'-3' RNA polymerase activity IDA
IDA: Inferred from direct assay
12482973 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
12482973 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA polymerase III complex IDA
IDA: Inferred from direct assay
12482973 GOA
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
33335104 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRCP Protein Structure

RNA_pol_Rpb4

RNA_pol_Rpb4: RNA polymerase Rpb4 (10 - 122)

  • 0
  • 100
  • 148 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase III subunit RPC9

  • CGRP-receptor component protein

  • RNA polymerase III subunit C9

  • calcitonin gene-related peptide-receptor component protein

CRCP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRCP O75575 ZMIZ2 Homo sapiens Q8NF64-2
Y2H Prey Pooling
25416956
Intra
CRCP O75575 TCF12 Homo sapiens Q99081
Validated Y2H
25416956
Intra
CRCP O75575 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra
CRCP O75575 ZMIZ2 Homo sapiens Q8NF64
Y2H Prey Pooling
25416956
Intra
CRCP O75575 ZMIZ2 Homo sapiens Q8NF64
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CRCP Antibodies

Cat. No. Product Name Application Reactivity
HY-P83605 CRCP Antibody (YA3350) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P83605A CRCP Antibody (YA3350)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Intracranial Hypertension

  • Raised Intracranial Pressure
Communicating Hydrocephalus

  • Acquired Communicating Hydrocephalus
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Overhydrated Hereditary Stomatocytosis

  • Ohs

  • Potassium Sodium Disorder Of Erythrocyte

  • OHST

  • Stomatocytosis I

  • Potassium-Sodium Disorder Of Erythrocyte

  • Stomatocytosisiohst

  • Hereditary, Overhydrated, Cation-Leak Stomatocytosis

  • Overhydrated Cation Leak Stomatocytosis

  • Stomatocytosis, Overhydrated Hereditary
Normal Pressure Hydrocephalus

  • Low Pressure Hydrocephalus

  • Hydrocephalus Normal Pressure

  • Hydrocephalus, Normal Pressure

  • Normal Pressure Hydrocephalus Nos

  • Nph - [Normal Pressure Hydrocephalus]

  • Normal Pressure Hydrocephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03144 CRCP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03145 Crcp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03146 Crcp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CRCP VGNC VGNC:39594
Felis catus CRCP VGNC VGNC:61163
Bos taurus CRCP VGNC VGNC:27691
Mus musculus CRCP MGD MGI:1100818
Macaca mulatta CRCP VGNC VGNC:71432
Rattus norvegicus CRCP RGD RGD:620753
Others CRCP NCBI