ZMIZ2 - zinc finger MIZ-type containing 2 Gene

Also Known as NET27; ZIMP7; hZIMP7; TRAFIP20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83637

Summary

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with Androgen Receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Ubiquitous expression in spleen (RPKM 17.3), skin (RPKM 13.4) and 25 other tissues.

ZMIZ2 Products (3)

mRNA Protein Name
NM_001300959.2 NP_001287888.1 zinc finger MIZ domain-containing protein 2 isoform 3
NM_031449.4 NP_113637.3 zinc finger MIZ domain-containing protein 2 isoform 1
NM_174929.2 NP_777589.2 zinc finger MIZ domain-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
16051670 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16051670 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in SMAD protein signal transduction IDA
IDA: Inferred from direct assay
16777850 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16051670 GOA
NOT involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16777850 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear replication fork IDA
IDA: Inferred from direct assay
16051670 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16051670 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMIZ2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMIZ2 Q8NF64 ARSJ Homo sapiens Q8N5N6
Y2H Array
25416956
Intra
ZMIZ2 Q8NF64 ARSJ Homo sapiens Q8N5N6
Y2H Prey Pooling
25416956
Intra
ZMIZ2 Q8NF64 CRCP Homo sapiens O75575
Y2H Array
25416956
Intra
ZMIZ2 Q8NF64 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra
ZMIZ2 Q8NF64 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16087 ZMIZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown