TSSK4 - testis specific serine kinase 4 Gene

Also Known as TSK4; TSK-4; TSSK5; STK22E; C14orf20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283629

Summary

This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Broad expression in testis (RPKM 10.7), spleen (RPKM 1.5) and 18 other tissues.

TSSK4 Products (3)

mRNA Protein Name
NM_001184739.2 NP_001171668.1 testis-specific serine/threonine-protein kinase 4 isoform 1
NM_001308067.2 NP_001294996.1 testis-specific serine/threonine-protein kinase 4 isoform 3
NM_174944.4 NP_777604.2 testis-specific serine/threonine-protein kinase 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15964553 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
15964553 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15964553 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15964553 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of CREB transcription factor activity IDA
IDA: Inferred from direct assay
15964553 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15964553 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSSK4 Q6SA08 CREB1 Homo sapiens P16220
Y2H
15964553
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15189 TSSK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16379 TSSK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20504 Tssk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27012 Tssk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown