DNAJC15 - DnaJ heat shock protein family (Hsp40) member C15 Gene

Also Known as MCJ; HSD18; DNAJD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29103

About DNAJC15

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,023,586-43,114,213 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 13.6), small intestine (RPKM 12.6) and 24 other tissues.

Summary

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. [provided by Alliance of Genome Resources, Apr 2022]

DNAJC15 Products (1)

mRNA	Protein	Name
NM_013238.3	NP_037370.2	dnaJ homolog subfamily C member 15

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23263864	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC15 Protein Structure

DnaJ

0
100
150 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily C member 15	DNAJ domain-containing

DNAJC15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAJC15	Q9Y5T4	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	DNAJC15	Q9Y5T4	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	DNAJC15	Q9Y5T4	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	DNAJC15	Q9Y5T4	PAM16	Homo sapiens	Q9Y3D7	Anti Tag CoIP	33961781
Intra	DNAJC15	Q9Y5T4	PAM16	Homo sapiens	Q9Y3D7	Anti Bait CoIP	23263864
Intra	DNAJC15	Q9Y5T4	PAM16	Homo sapiens	Q9Y3D7	Pull Down	23263864
Intra	DNAJC15	Q9Y5T4	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	DNAJC15	Q9Y5T4	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DNAJC15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83237	MCJ Antibody (YA2982)	WB, IHC-P	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03878	DNAJC15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29505	Dnajc15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DNAJC15	VGNC	VGNC:53812
Felis catus	DNAJC15	VGNC	VGNC:102185
Rattus norvegicus	DNAJC15	RGD	RGD:1307154
Mus musculus	DNAJC15	MGD	MGI:1913398
Macaca mulatta	DNAJC15	VGNC	VGNC:106258