Snca - synuclein alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29219

About Snca

Primary_assembly 4: 89,696,420-89,796,262 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 189 orthologues, 2 paralogues and is associated with 35 phenotypes. Biased expression in Brain (RPKM 542.3), Spleen (RPKM 92.9) and 1 other tissue.

Summary

Enables several functions, including Phospholipase binding activity; protein N-terminus binding activity; and tubulin binding activity. Involved in several processes, including behavioral response to cocaine; negative regulation of nitrogen compound metabolic process; and response to desipramine. Located in several cellular components, including cytoplasmic vesicle; distal axon; and mitochondrion. Used to study Parkinson's disease and amphetamine abuse. Biomarker of mental depression and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Snca Products (1)

mRNA Protein Name
NM_019169.3 NP_062042.1 alpha-synuclein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
18800064 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
11943812 RGD
enables microtubule binding IDA
IDA: Inferred from direct assay
11698390 RGD
enables phospholipase binding IPI
IPI: Inferred from physical interaction
11821392 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
11679584 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11032911 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11821392 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
18001274 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
12562524 RGD
involved in negative regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11943812 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17635667 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
11943812 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
14622225 RGD
involved in response to desipramine IEP
IEP: Inferred from expression pattern
19818834 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
12127102 RGD
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
11943812 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12821390 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19429081 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
19429081 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
19429081 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
11943812 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17275196 RGD
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
11810180 RGD
located in presynapse IDA
IDA: Inferred from direct assay
12000718 RGD
located in ribosome IDA
IDA: Inferred from direct assay
11810180 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
18001274 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
10777786 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Snca Protein Structure

Synuclein

Synuclein: pfam01387 (0 - 102)

  • 0
  • 100
  • 149 a.a.
Protein Preferred Names Protein Names

alpha-synuclein

  • synuclein, alpha (non A4 component of amyloid precursor)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990898 Amlenetug 99.85% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135902A Synucleozid hydrochloride Inhibitor 98.23% Unkown
HY-135902 Synucleozid Inhibitor / Unkown
HY-125984 Syn-516 Inhibitor / Unkown
HY-401209 Synucleozid-2.0 Inhibitor 98.01% Unkown
HY-RS13482 SNCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13483 Snca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13484 Snca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990922 Indenebart 99.53% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snca NCBI NCBI:6622