Cfl1 - cofilin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29271

Summary

Enables actin filament binding activity; phosphatidylinositol bisphosphate binding activity; and protein Phosphatase binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular component organization; and positive regulation of cellular component organization. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including cofilin-actin rod; growth cone; and lamellipodium. Is active in glutamatergic synapse. Used to study myocardial infarction. Biomarker of several diseases, including epilepsy (multiple); impotence; muscular atrophy; ureteral obstruction; and vitamin B12 deficiency. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 Products (2)

mRNA Protein Name
NM_017147.3 NP_058843.1 cofilin-1
NM_017147.3 NP_058843.1 cofilin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IMP
IMP: Inferred from mutant phenotype
12566455 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
24740405 RGD
enables phosphatidylinositol bisphosphate binding IPI
IPI: Inferred from physical interaction
19029335 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19704022 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
26324884 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell projection organization IDA
IDA: Inferred from direct assay
16286931 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
26324884 RGD
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
23704350 RGD
involved in cellular response to ether IEP
IEP: Inferred from expression pattern
24239914 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
23765104 RGD
involved in cellular response to insulin-like growth factor stimulus IDA
IDA: Inferred from direct assay
24195677 RGD
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
24760020 RGD
involved in cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
24760020 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
24760020 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
27073215 RGD
involved in modification of postsynaptic actin cytoskeleton EXP
EXP: Inferred from Experiment
16025109 RGD
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
16025109 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
16025109 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
16025109 RGD
involved in negative regulation of actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in negative regulation of actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
15252126 RGD
involved in negative regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
26169356 RGD
involved in negative regulation of cell motility IMP
IMP: Inferred from mutant phenotype
24093776 RGD
acts upstream of or within negative regulation of cell size IDA
IDA: Inferred from direct assay
16286931 RGD
involved in negative regulation of dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
23974706 RGD
involved in negative regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in negative regulation of postsynaptic density organization IMP
IMP: Inferred from mutant phenotype
26169356 RGD
involved in negative regulation of unidimensional cell growth IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in positive regulation of NMDA glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
24089484 RGD
involved in positive regulation of barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
23704350 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in positive regulation of cell motility IMP
IMP: Inferred from mutant phenotype
24214978 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
25723479 RGD
involved in positive regulation of establishment of cell polarity regulating cell shape IMP
IMP: Inferred from mutant phenotype
26169356 RGD
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
15252126 RGD
involved in positive regulation of protein localization to cell leading edge IMP
IMP: Inferred from mutant phenotype
26324884 RGD
involved in positive regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
24093776 RGD
involved in positive regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
25723479 RGD
involved in protein import into nucleus IMP
IMP: Inferred from mutant phenotype
12566455 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
26678157 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
26678157 RGD
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
15252126 RGD
located in cofilin-actin rod IDA
IDA: Inferred from direct assay
24760020 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
24760020 RGD
located in filopodium IDA
IDA: Inferred from direct assay
24515839 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16025109 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16025109 RGD
located in growth cone IDA
IDA: Inferred from direct assay
24515839 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
15252126 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
27642592 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
24515839 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
25708984 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cofilin-1

  • cofilin 1, non-muscle

Cfl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cfl1 P45592 Cttn Rattus norvegicus Q66HL2
Anti Bait CoIP
19704022
Intra
Cfl1 P45592 Cttn Rattus norvegicus Q66HL2
Anti Tag CoIP
19704022
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15700 VPS72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125444 TH251 Inhibitor / Unkown
HY-RS02568 CFL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18607 Cfl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25093 Cfl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfl1 NCBI NCBI:1072